The many roles of microRNAs in brain tumor biology

被引：60

作者：

Turner, Jay D. ^{[1
]}

Williamson, Richard ^{[1
]}

Almefty, Kaith K. ^{[1
]}

Nakaji, Peter ^{[1
]}

Porter, Randall ^{[1
]}

Tse, Victor ^{[2
]}

Kalani, M. Yashar S. ^{[1
]}

机构：

[1] Barrow Neurol Inst, Div Neurosurg, Phoenix, AZ 85013 USA

[2] Permanente Med Grp Inc, Dept Neurosurg, Redwood City, CA USA

来源：

NEUROSURGICAL FOCUS | 2010年 / 28卷 / 01期

关键词：

microRNA; glioma; medulloblastoma; cancer stem cell; CANCER STEM-CELLS; CHRONIC LYMPHOCYTIC-LEUKEMIA; SONIC HEDGEHOG; HUMAN MEDULLOBLASTOMA; DOWN-REGULATION; OVARIAN-CANCER; GLIOMA-CELLS; IN-VIVO; EXPRESSION; GLIOBLASTOMA;

D O I：

10.3171/2009.10.FOCUS09207

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

MicroRNAs (miRNAs) are now recognized as the primary RNAs involved in the purposeful silencing of the cell's own message. In addition to the established role of miRNAs as developmental regulators of normal cellular function, they have recently been shown to be important players in pathological states such as cancer. The authors review the literature on the role of miRNAs in the formation and propagation of gliomas and medulloblastomas, highlighting the potential of these molecules and their inhibitors as therapeutics. (DOI: 10.3171/2009.10.FOCUS09207)

引用

页码：E3.1 / E3.7

页数：7

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