Impaired gait kinematics in type 1 Gaucher's Disease

被引：17

作者：

Sorrentino, Pierpaolo ^{[1
,2
]}

Barbato, Antonio ^{[3
]}

Del Gaudio, Luigi ^{[1
]}

Rucco, Rosaria ^{[4
,5
]}

Varriale, Pasquale ^{[4
,5
]}

Sibilio, Michelina ^{[6
]}

Strazzullo, Pasquale ^{[3
]}

Sorrentino, Giuseppe ^{[4
,5
]}

Agosti, Valeria ^{[4
,5
]}

机构：

[1] Univ Naples Federico II, Dept Neurosci Reprod & Odontostomatol Sci, Naples, Italy

[2] Vrije Univ Amsterdam Med Ctr, Dept Clin Neurophysiol, Amsterdam, Netherlands

[3] Univ Naples Federico II, Dept Clin Med, Naples, Italy

[4] Univ Naples Parthenope, Dept Motor Sci & Wellness, Naples, Italy

[5] Inst Hermitage Capodimonte, Naples, Italy

[6] Moscati Hosp, Div Pediat, Aversa, CE, Italy

来源：

JOURNAL OF PARKINSONS DISEASE | 2016年 / 6卷 / 01期

关键词：

Gaucher's disease; gait analysis; joint excursion; extrapyramidal system; Parkinson disease; parkinsonism; HEALTHY ELDERLY SUBJECTS; PARKINSONS-DISEASE; GLUCOCEREBROSIDASE MUTATIONS; INVOLVEMENT; CARRIERS;

D O I：

10.3233/JPD-150660

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Type 1 Gaucher's disease (GD1) is traditionally regarded as "non-neurological". Spatiotemporal and kinematic analysis of gait was carried on thirteen GD1 patients and thirteen healthy controls. We identified a previously unknown subclinical reduction of amplitude of movements in GD1. Articular excursion of ankle, knee and hip was reduced during the swing phase of gait (p<0.0001). Furthermore, the excursion of the knee appeared also significantly more asymmetric in GD1 patients (p = 0.02). Correction for age, BMI and basal walking speed did not modify the significance. Accordingly to the recent observations that GD1 predisposes to Parkinson's disease, the impaired and asymmetric gait kinematics that we observed might be interpreted as a form of extrapyramidal involvement.

引用

页码：191 / 195

页数：5

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