Overexpression of UDP-Glucose 4-Epimerase Is Associated with Differentiation Grade of Gastric Cancer

被引：5
|
作者：
Deodato de Souza, Maria de Fatima [1 ]
da Silva Filho, Antonio Felix [1 ]
de Barros Albuquerque, Amanda Pinheiro [1 ]
Leal Quirino, Michael Williams [1 ]
de Souza Albuquerque, Mario Sergio [1 ]
Cordeiro, Marina Ferraz [1 ,2 ]
Martins, Mario Rino [3 ]
Pitta, Ivan da Rocha [1 ]
Lucena-Araujo, Antonio Roberto [4 ]
da Rocha Pitta, Maira Galdino [1 ]
Barreto de Melo Rego, Moacyr Jesus [1 ]
机构：
[1] Univ Fed Pernambuco, Nucleo Pesquisa Inovacao Terapeut Suely Galdino N, LINAT, Recife, PE, Brazil
[2] Univ Fed Vale Sao Francisco, Colegiado Med, Paulo Afonso, BA, Brazil
[3] HCP, Recife, PE, Brazil
[4] Univ Fed Pernambuco, Dept Genet, Recife, PE, Brazil
来源：
DISEASE MARKERS | 2019年 / 2019卷
关键词：
CLASSIFICATION; EPIDEMIOLOGY;
D O I：
10.1155/2019/6325326
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The UDP-glucose 4-epimerase (GALE) is a glycosyltransferase, which acts on protein and lipid glycosylation in normal and neoplastic cells. This study is aimed at investigating the differential tissue expression of GALE and its possible association with clinical-pathological parameters and the outcome of gastric adenocarcinoma patients. Seventy-one patients were evaluated in relation to GALE expression by immunohistochemistry. Our results showed that 48 (67.6%) patients were GALE positive and 23 (32.4%) negative. Positive staining was present on well-differentiated and moderate-differentiated histological grade of gastric adenocarcinomas (p<0.0001). There was no significant association with outcome parameters (p>0.05). Besides that, our results corroborated with the validation cohort analysis, where the expression of GALE mRNA was also associated with the histological grade (p<0.001). These results suggest a possible use of this enzyme as a biomarker for well and moderately differentiated tumors.
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页数：5
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