Oral immunization with recombinant Yersinia enterocolitica expressing a measles virus CD4 T cell epitope protects against measles virus-induced encephalitis

被引：12

作者：

Gundel, I

Weidinger, G

ter Meulen, V

Heesemann, A

Rüssmann, H

Niewiesk, S

机构：

[1] Univ Wurzburg, Inst Virol & Immunbiol, D-97078 Wurzburg, Germany

[2] Max Von Pettenkofer Inst Hyg & Med Microbiol, Munich, Germany

来源：

JOURNAL OF GENERAL VIROLOGY | 2003年 / 84卷

关键词：

D O I：

10.1099/vir.0.18834-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Immunization via the oral route with an attenuated Yersinia enterocolitica strain expressing a fragment of the measles virus nucleocapsid protein (aa 79-161) via its type III protein secretion system induced a T helper type 1 response in immunized C3H mice, which conferred protection against measles virus-induced encephalitis in a time- and dose-dependent manner.

引用

页码：775 / 779

页数：5

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