Oral immunization with recombinant Yersinia enterocolitica expressing a measles virus CD4 T cell epitope protects against measles virus-induced encephalitis

被引：12
|
作者：
Gundel, I
Weidinger, G
ter Meulen, V
Heesemann, A
Rüssmann, H
Niewiesk, S
机构：
[1] Univ Wurzburg, Inst Virol & Immunbiol, D-97078 Wurzburg, Germany
[2] Max Von Pettenkofer Inst Hyg & Med Microbiol, Munich, Germany
来源：
JOURNAL OF GENERAL VIROLOGY | 2003年 / 84卷
关键词：
D O I：
10.1099/vir.0.18834-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Immunization via the oral route with an attenuated Yersinia enterocolitica strain expressing a fragment of the measles virus nucleocapsid protein (aa 79-161) via its type III protein secretion system induced a T helper type 1 response in immunized C3H mice, which conferred protection against measles virus-induced encephalitis in a time- and dose-dependent manner.
引用
收藏
页码：775 / 779
页数：5
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