High-Intensity Focused Ultrasound for Noninvasive Functional Neurosurgery

被引：349
|
作者：
Martin, Ernst [1 ]
Jeanmonod, Daniel [2 ]
Morel, Anne [2 ]
Zadicario, Eyal [3 ]
Werner, Beat [1 ]
机构：
[1] Univ Childrens Hosp Zurich, MR Ctr, CH-8032 Zurich, Switzerland
[2] Univ Childrens Hosp Zurich, Dept Funct Neurosurg, Zurich, Switzerland
[3] InSightec Ltd, Tirat Carmel, Israel
来源：
ANNALS OF NEUROLOGY | 2009年 / 66卷 / 06期
关键词：
TISSUE-DAMAGE; MRI; BRAIN; SURGERY; THRESHOLD; THALAMUS; LESIONS;
D O I：
10.1002/ana.21801
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Transcranial magnetic resonance (MR)-guided high-intensity focused ultrasound (tcMRgHIFU) implies a novel, noninvasive treatment strategy for various brain diseases. Nine patients with chronic neuropathic pain were treated with selective medial thalamotomies. Precisely located thermal ablations of 4mm, in diameter were produced at peak temperatures of 51 degrees C to 60 degrees C under continuous visual MR guidance and MR thermometry. The resulting lesions are clearly visible on follow-up MR imaging. All treatments were well tolerated, without side effects or neurological deficits. This is the First report on successful clinical application of tcMRgHIFU in functional brain disorders, portraying it as safe and reliable for noninvasive neurosurgical interventions. Ann Neurol 2009;66:858-861
引用
收藏
页码：858 / 861
页数：4
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