Staphylococcus aureus antimicrobial efflux pumps and their inhibitors: recent developments

被引：6
|
作者：
Lekshmi, Manjusha [1 ]
Stephen, Jerusha [1 ]
Ojha, Manisha [2 ]
Kumar, Sanath [1 ]
Varela, Manuel [2 ]
机构：
[1] ICAR Cent Inst Fisheries Educ, Postharvest Technol, Mumbai 400061, Maharashtra, India
[2] Eastern New Mexico Univ, Dept Biol, Stn 33, Portales, NM 88130 USA
来源：
AIMS MEDICAL SCIENCE | 2022年 / 9卷 / 03期
基金：
美国国家卫生研究院;
关键词：
antimicrobial efflux; bacteria; efflux pump inhibitors; modulation; multidrug resistance; pathogens; Staphylococcus aureus; QUATERNARY AMMONIUM-COMPOUNDS; MAJOR FACILITATOR SUPERFAMILY; MULTIDRUG-RESISTANCE; LACTOSE CARRIER; DISINFECTANT RESISTANCE; ANTIBIOTIC-RESISTANCE; NUCLEOTIDE-SEQUENCE; ESCHERICHIA-COLI; FLUOROQUINOLONE RESISTANCE; BACTERIAL-RESISTANCE;
D O I：
10.3934/medsci.2022018
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The microorganism Staphylococcus aureus is a notorious causative agent of bacterial infection. The widespread presence of this pathogen has caused significant morbidity and mortality rates in clinical healthcare settings and communities. Due to its increasingly frequent recalcitrant nature towards clinically available antimicrobial agents, the bacterium poses a considerable public health crisis. A significant bacterial mechanism of antimicrobial agent resistance includes multidrug efflux pump systems. These antimicrobial efflux determinants translate into several large superfamilies of transporters that share related amino acid sequences, similarities in three-dimensional structures, modes of energization, and solute transport catalysis across the membrane. Because of their ubiquitous nature and functional role in virulence, these multidrug transporters make good targets for inhibition. This review briefly summarizes recent key findings regarding multidrug efflux activity and modulation in the MATE, SMR, and MFS transporters.
引用
收藏
页码：367 / 393
页数：27
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