Synthesis of 5-Aryl- and 5-Heteroaryl-7-carboxyl-8-hydroxyquinaldines through Suzuki Cross-Coupling Reaction with Potassium Organotrifluoroborates

被引：5
|
作者：
Sliman, Faten [1 ]
Desmaele, Didier [1 ]
机构：
[1] Univ Paris Sud, Fac Pharm, CNRS, UMR 8076, F-92296 Chatenay Malabry, France
来源：
SYNTHESIS-STUTTGART | 2010年 / 04期
关键词：
quinolines; cross-coupling; boron; palladium; arylations; HIV-1 INTEGRASE INHIBITORS; TRANSFER HYDROGENATION; ARYLBORONIC ACIDS; PALLADIUM; REPLICATION; COMPLEXES; ARYL; 8-HYDROXYQUINOLINE; 1,4-CYCLOHEXADIENE; STYRYLQUINOLINES;
D O I：
10.1055/s-0029-1218585
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 5-aryl- and 5-heteroaryl-7-carboxyl-8-hydroxyquinaldines were prepared from 5-bromo-7-methoxycarbonyl-8-benzyloxyquinaldine based on the Suzuki cross-coupling reaction using potassium organotrifluoroborates. An efficient method of deprotection of the 8-hydroxy group using a microwaveassisted hydrogen transfer reaction is reported.
引用
收藏
页码：619 / 630
页数：12
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