Transcription Regulators and Hormones Involved in the Development of Brown Fat and White Fat Browning: Transcriptional and Hormonal Control of Brown/Beige Fat Development

被引：28

作者：

Zhang, Jianmei ^{[1
,2
,4
]}

Wu, Huixiao ^{[1
,2
]}

Ma, Shizhan ^{[1
,2
]}

Jing, Fei ^{[1
,2
]}

Yu, Chunxiao ^{[1
,2
]}

Gao, Ling ^{[2
,3
]}

Zhao, Jiajun ^{[1
,2
]}

机构：

[1] Shandong Univ, Shandong Prov Hosp, Dept Endocrinol, 324 Jing 5 Rd, Jinan 250021, Shandong, Peoples R China

[2] Shandong Prov Key Lab Endocrinol & Lipid Metab, 324 Jing 5 Rd, Jinan 250021, Shandong, Peoples R China

[3] Shandong Acad Clin Med, Inst Endocrinol & Metab, Jinan, Shandong, Peoples R China

[4] Weihai Municipal Hosp, Dept Geriatr, Weihai, Shandong, Peoples R China

来源：

PHYSIOLOGICAL RESEARCH | 2018年 / 67卷 / 03期

关键词：

Brown adipose; Beige adipose; Browning; Hormones; Transcription regulators; INCREASES ENERGY-EXPENDITURE; ADIPOSE-TISSUE THERMOGENESIS; IMPROVES INSULIN SENSITIVITY; UNCOUPLING PROTEIN-1 GENE; THYROID-HORMONE; SKELETAL-MUSCLE; ADRENERGIC-STIMULATION; SIGNAL INTEGRATION; ACID OXIDATION; BEIGE FAT;

D O I：

10.33549/physiolres.933650

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The high prevalence of obesity and related metabolic complications has inspired research on adipose tissues. Three kinds of adipose tissues are identified in mammals: brown adipose tissue (BAT), beige or brite adipose tissue and white adipose tissue (WAT). Beige adipocytes share some characteristics with brown adipocytes such as the expression of UCP1. Beige adipocytes can be activated by environmental stimuli or pharmacological treatment, and this change is accompanied by an increase in energy consumption. This process is called white browning, and it facilitates the maintenance of a lean and healthy phenotype. Thus, promoting beige adipocyte development in WAT shows promise as a new strategy in treating obesity and related metabolic consequences. In this review, we summarized the current understanding of the regulators and hormones that participate in the development of brown fat and white fat browning.

引用

页码：347 / 362

页数：16

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