Catalytic asymmetric Horner-Wadsworth-Emmons reaction under phase-transfer-catalyzed conditions

被引：80
|
作者：
Arai, S [1 ]
Hamaguchi, S [1 ]
Shioiri, T [1 ]
机构：
[1] Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 19期
关键词：
asymmetric reactions; catalysts; olefination; phase transfer;
D O I：
10.1016/S0040-4039(98)00442-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The catalytic asymmetric Homer-Wadsworth-Emmons reaction promoted by quaternary ammonium salts derived from cinchonine as a phase-transfer catalyst is described. Treatment of the prochiral ketone 1 with phosphonates under mild reaction conditions afforded the corresponding desired products in moderate enantiomeric excess. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2997 / 3000
页数：4
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