Biomarkers in systemic sclerosis

被引：66

作者：

Castro, Susan V. ^{[1
]}

Jimenez, Sergio A. ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Inst Mol Med, Philadelphia, PA 19107 USA

来源：

BIOMARKERS IN MEDICINE | 2010年 / 4卷 / 01期

关键词：

biomarker; endothelial cells; fibrosis; pulmonary artery hypertension; pulmonary fibrosis; scleroderma; systemic sclerosis; TGF-beta; ENDOTHELIAL GROWTH-FACTOR; PULMONARY ARTERIAL-HYPERTENSION; SOLUBLE ADHESION MOLECULES; INTERSTITIAL LUNG-DISEASE; VON-WILLEBRAND-FACTOR; COLLAGEN DEGRADATION-PRODUCTS; OLIGOMERIC MATRIX PROTEIN; IN-SITU EXPRESSION; SERUM-LEVELS; NATRIURETIC PEPTIDE;

D O I：

10.2217/BMM.09.79

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiology characterized by pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often progressive fibrotic process. Numerous biomarkers reflecting the three main pathogenetic mechanisms in systemic sclerosis have been described; however, aside from several disease-specific autoantibodies, other biomarkers have not been thoroughly validated and require further study. Thus, there is an unmet need for validated biomarkers for diagnosis, disease classification, and evaluation of organ involvement and therapeutic response in systemic sclerosis.

引用

页码：133 / 147

页数：15

共 50 条

[41] Induced sputum in systemic sclerosis: A new potential for biomarkers in SSc
Jacquerie, Pierre
Andre, Beatrice
Henquet, Monique
Moermans, Catherine
De Seny, Dominique
Gester, Fanny
Louis, Renaud
Malaise, Michel
Guiot, Julien
EUROPEAN RESPIRATORY JOURNAL, 2019, 54
[42] Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers
Cavazzana, Ilaria
Vojinovic, Tamara
Airo', Paolo
Fredi, Micaela
Ceribelli, Angela
Pedretti, Eleonora
Lazzaroni, Maria Grazia
Garrafa, Emirena
Franceschini, Franco
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2023, 64 (03) : 412 - 430
[43] Biomarkers for Pulmonary Vascular Remodeling in Systemic Sclerosis: A Pathophysiological Approach
Odler, Balazs
Foris, Vasile
Gungl, Anna
Muller, Veronika
Hassoun, Paul M.
Kwapiszewska, Grazyna
Olschewski, Horst
Kovacs, Gabor
FRONTIERS IN PHYSIOLOGY, 2018, 9
[44] Endostatin, Potential Biomarkers For Lung Involvement In Subjects With Systemic Sclerosis
Van Eeden, S.
Salami, S.
Lo, E.
Baron, M.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183
[45] ANGIOGENIC BIOMARKERS PREDICT THE OCCURRENCE OF DIGITAL ULCERS IN SYSTEMIC SCLEROSIS
Avouac, J.
Meune, C.
Kahan, A.
Chiocchia, G.
Allanore, Y.
ANNALS OF THE RHEUMATIC DISEASES, 2013, 71 : 116 - 116
[46] Serum metabolomic profiling reveals potential biomarkers in systemic sclerosis
Guo, Muyao
Liu, Di
Jiang, Yu
Chen, Weilin
Zhao, Lijuan
Bao, Ding
Li, Yisha
Distler, Jorg H. W.
Zhu, Honglin
METABOLISM-CLINICAL AND EXPERIMENTAL, 2023, 144
[47] Identification of Biomarkers Predictive of Pulmonary Arterial Hypertension in Systemic Sclerosis
Kolstad, Kathleen D.
Holmes, Tyson
Rosenberg-Hasson, Yael
Sweatt, Andrew
Zamanian, Roham T.
Li, Shufeng
Steen, Virginia D.
Utz, Paul J.
Chung, Lorinda
ARTHRITIS & RHEUMATOLOGY, 2017, 69
[48] BIOMARKERS SENSITIVE TO CHANGE IN PATIENTS WITH SYSTEMIC SCLEROSIS - A SYSTEMATIC REVIEW
Toniolo, M.
Dobrota, R.
Moinzadeh, P.
Ogawa, R.
Furst, D. E.
Denton, C. P.
Khanna, D.
Distler, O.
ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 : 1140 - 1140
[49] EVALUATION OF ANGIOGENIC AND FIBROGENIC CYTOKINES AS BIOMARKERS IN SUBGROUPS OF SYSTEMIC SCLEROSIS
Patterson, Karen
Sakko, Andrew
Ricciardelli, Carmela
Proudman, Susanna
Hissaria, Pravin
INTERNAL MEDICINE JOURNAL, 2011, 41 : 9 - 10
[50] Angiogenic biomarkers predict the occurrence of digital ulcers in systemic sclerosis
Avouac, Jerome
Meune, Christophe
Ruiz, Barbara
Couraud, Pierre Olivier
Uzan, Georges
Boileau, Catherine
Kahan, Andre
Chiocchia, Gilles
Allanore, Yannick
ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (03) : 394 - 399

← 1 2 3 4 5 →