Risk of acute kidney injury in patients with HIV receiving proton pump inhibitors

被引：8

作者：

Sutton, S. Scott ^{[1
,2
]}

Magagnoli, Joseph ^{[2
]}

Cummings, Tammy H. ^{[2
]}

Hardin, James W. ^{[3
]}

机构：

[1] Univ South Carolina, South Carolina Coll Pharm, Dept Clin Pharm & Outcomes Sci, 715 Sumter St CLS 314b, Columbia, SC 29208 USA

[2] WJB Dorn Vet Affairs Med Ctr, Dorn Res Inst, Columbia, SC 29209 USA

[3] Univ South Carolina, Biostat Div, Dept Epidemiol & Biostat, 1600 Hampton St,Suite 507,Room 539, Columbia, SC 29208 USA

来源：

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2019年 / 8卷 / 10期

关键词：

acute kidney injury; HIV; proton pump inhibitors; ACUTE INTERSTITIAL NEPHRITIS; ACUTE-RENAL-FAILURE; TENOFOVIR DISOPROXIL FUMARATE; T-CELL-ACTIVATION; VIRAL SUPPRESSION; INFECTED PATIENTS; MORTALITY; ADHERENCE; IMPACT; ADULTS;

D O I：

10.2217/cer-2019-0017

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Aims/patients & methods: To evaluate the risk of acute kidney injury (AKI) in patients with HIV receiving proton pump inhibitors (PPI) a cohort study was conducted utilizing the Veterans Affairs Informatics and Computing Infrastructure (VINCI) database. Patients were followed from the index date until the earliest date of AKI, 120 days or end of study period, or death. Statistical analyses utilized a Cox proportional hazards model. Results: A total of 21,643 patients (6000 PPI and 15,643 non-PPI) met all study criteria. The PPI cohort had twice the risk of AKI compared with controls (2.12, hazard ratio: 1.46-3.1). Conclusion: A nationwide cohort study supported the relationship of an increased risk of AKI in patients receiving PPIs.

引用

页码：781 / 790

页数：10

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