The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics

被引：57

作者：

O'Bryant, Sid E. ^{[1
,2
]}

Johnson, Leigh A. ^{[1
,2
]}

Barber, Robert C. ^{[1
,2
]}

Braskie, Meredith N. ^{[3
]}

Christian, Bradley ^{[4
,5
]}

Hall, James R. ^{[1
,2
]}

Hazra, Nalini ^{[3
]}

King, Kevin ^{[6
]}

Kothapalli, Deydeep ^{[3
]}

Large, Stephanie ^{[1
,2
]}

Mason, David ^{[7
]}

Matsiyevskiy, Elizabeth ^{[3
]}

McColl, Roderick ^{[8
]}

Nandy, Rajesh ^{[1
,9
]}

Palmer, Raymond ^{[10
]}

Petersen, Melissa ^{[1
,7
]}

Philips, Nicole ^{[1
,2
]}

Rissman, Robert A. ^{[11
,12
]}

Shi, Yonggang ^{[13
]}

Toga, Arthur W. ^{[13
]}

Vintimilla, Raul ^{[1
,2
]}

Vig, Rocky ^{[14
]}

Zhang, Fan ^{[1
,7
]}

Yaffe, Kristine ^{[15
,16
]}

机构：

[1] Univ North Texas, Hlth Sci Ctr, Inst Translat Res, Ft Worth, TX 76107 USA

[2] Univ North Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX 76107 USA

[3] USC, Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Keck Sch Med, Los Angeles, CA USA

[4] Univ Wisconsin, Waisman Ctr, Dept Phys, Madison, WI 53705 USA

[5] Univ Wisconsin, Waisman Ctr, Dept Psychiat, Madison, WI 53705 USA

[6] Barrow Neurol Inst, Dept Neuroradiol, Phoenix, AZ 85013 USA

[7] Univ North Texas, Hlth Sci Ctr, Dept Family Med, Ft Worth, TX 76107 USA

[8] UT Southwestern Med Ctr, Dept Radiol, Dallas, TX USA

[9] Univ North Texas, Hlth Sci Ctr, Dept Biostat & Epidemiol, Ft Worth, TX 76107 USA

[10] Univ Texas Hlth Sci Ctr San Antonio, Dept Family Practice & Community Med, Joe R & Teresa Lozano Long Sch Med, San Antonio, TX 78229 USA

[11] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[12] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA

[13] Univ Southern Calif, USC, Keck Sch Med, Lab Neuro Imaging,Stevens Neuroimaging & Informat, Los Angeles, CA USA

[14] Midtown Med Imaging, Imaging, Ft Worth, TX USA

[15] Univ Calif San Francisco, Dept Psychiat Neurol & Epidemiol & Biostat, San Francisco, CA 94143 USA

[16] San Francisco VA Med Ctr, San Francisco, CA USA

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2021年 / 13卷 / 01期

关键词：

Alzheimer's disease; amyloid; biomarkers; diversity; Hispanic; Mexican American; mild cognitive impairment; neurodegeneration; MILD COGNITIVE IMPAIRMENT; RATING-SCALE SUM; ALZHEIMERS-DISEASE; PROTEOMIC SIGNATURE; NATIONAL INSTITUTE; NORMATIVE DATA; VALIDATION; DEMENTIA; DECLINE; DEPRESSION;

D O I：

10.1002/dad2.12202

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature. Methods Community-dwelling Mexican Americans and non-Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository. Results Data was examined from n = 1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non-Hispanic Whites. Discussion The current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations.

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页数：10

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