SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME NEW 2-(3-PYRIDIL)-THIAZOLYL-1,3,4-OXADIAZOLINES

被引：0
|
作者：
Oniga, Smaranda Dafina [1 ]
Araniciu, Catalin [1 ]
Stoica, Cristina Ioana [1 ]
Palage, Mariana Doina [1 ]
Vlase, Laurian [2 ]
Pirnau, Adrian [3 ]
Marutescu, Luminita [4 ,5 ]
Chifiriuc, Mariana Carmen [4 ,5 ]
Oniga, Ovidiu [6 ]
机构：
[1] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Therapeut Chem, 12 Ion Creanga St, Cluj Napoca 400010, Romania
[2] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Technol & Biopharm, 41 Victor Babes St, Cluj Napoca 400012, Romania
[3] Natl Inst Res & Dev Isotop & Mol Technol, 65-103 Donat St, Cluj Napoca 400293, Romania
[4] Univ Bucharest, Fac Biol, Dept Microbiol, 1-3 Portocalelor St, Bucharest 60101, Romania
[5] Univ Bucharest, Res Inst, ICUB, 91-95 Independentei St, Bucharest, Romania
[6] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Chem, 41 Victor Babes St, Cluj Napoca 400012, Romania
来源：
FARMACIA | 2017年 / 65卷 / 04期
关键词：
thiazole; oxadiazoline; antimicrobial activity; DERIVATIVES; CHALLENGES;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A new series of 4-methyl-2-(pyridin-3-yI)-thiazole-5-yl-oxadiazolines were synthesized starting from 4-methy1-2-(pyridin-3-yl)thiazole-5-carbohydrazide. The newly synthesized compounds were characterized by analytical H-1-NMR, C-13-NMR and mass spectral data. These compounds were screened for their antimicrobial activity against Gram-positive and Gram-negative bacterial strains and one fungal strain (Candida albicans).
引用
收藏
页码：501 / 507
页数：7
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