Synthesis and biological activities on batzelladine derivatives

被引：0

作者：

Shimokawa, Jun ^{[1
]}

Iijima, Yumi

Hashimoto, Yuichi

Chiba, Harumi

Tanaka, Haruo

Nagasawa, Kazuo

机构：

[1] Tokyo Univ Agr & Technol, Dept Biotechnol & Life Sci, Tokyo 1848588, Japan

[2] Univ Tokyo, Inst Mol & Cellular Biol, Tokyo 1130032, Japan

[3] Kitasato Univ, Sch Pharmaceut Sci, Tokyo 1088641, Japan

来源：

HETEROCYCLES | 2007年 / 72卷

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Structure-activity relationship studies on batzelladines A and D were examined. Seven batzelladine derivatives, including 24-epi-batzelladine A (3) and 7-epi-batzelladine D (4), were synthesized. The inhibitory activity of these derivatives on binding of gp120 with CD4 was evaluated by the use of ELISA-based assay method. For the potent biological activities of batzelladines, tricyclic guanidine moiety, a common structure of batzelladine A and D, and side chain bearing guanidine functional group were found to be mandatory.

引用

页码：145 / 150

页数：6

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