AMN107, novel aminopyrimidine inhibitor of Bcr-Abl, is significantly more potent than imatinib mesylate against Philadelphia chromosome positive acute lymphoblastic leukemia cells.

被引：0
|
作者：
Golemovic, M
Beran, M
Giles, F
Manshouri, T
Thomas, D
Cortes, J
Manley, P
Alland, L
Rae, P
Dugan, M
Estrov, Z
Arlinghaus, RB
Kantarjian, H
Verstovsek, S
机构：
[1] Univ Texas, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA
[2] Novartis Pharmaceut, Basel, Switzerland
来源：
BLOOD | 2004年 / 104卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
2737
引用
收藏
页码：748A / 748A
页数：1
相关论文
共 50 条
  • [31] Serial monitoring of BCR-ABL in newly diagnosed Philadelphia chromosome-positive (Ph plus ) acute lymphoblastic leukemia (ALL) treated with imatinib.
    Lim, Sung-Nam
    Joo, Young-Don
    Kim, Ii-Hwan
    Lee, Won-Sik
    Lee, Sang Min
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [32] The development of agents targeting the BCR-ABL tyrosine kinase as Philadelphia chromosome-positive acute lymphoblastic leukemia treatment
    Thomas, Xavier
    Heiblig, Mael
    EXPERT OPINION ON DRUG DISCOVERY, 2016, 11 (11) : 1061 - 1070
  • [33] The existence of lymphoid lineage restricted Philadelphia chromosome-positive acute lymphoblastic leukemia with heterogeneous bcr-abl rearrangement
    L Pajor
    JA Vass
    L Kereskai
    P Kajtár
    Á Szomor
    M Egyed
    J Iványi
    P Jáksó
    Leukemia, 2000, 14 : 1122 - 1126
  • [34] A phase II study of AMN107, a novel inhibitor of Bcr-Abl, administered to imatinib-resistant or intolerant patients (pts) with chronic myelogenous leukemia (CML) in accelerated phase (AP).
    Le Coutre, P. D.
    Ottmann, O.
    Gatterman, N.
    Larson, R.
    Rafferty, T.
    Alland, L.
    Tavorath, R.
    Giles, F.
    O'Brien, S. G.
    Kantarjian, H.
    JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (18) : 344S - 344S
  • [35] The existence of lymphoid lineage restricted Philadelphia chromosome-positive acute lymphoblastic leukemia with heterogeneous bcr-abl rearrangement
    Pajor, L
    Vass, JA
    Kereskai, L
    Kajtár, P
    Szomor, A
    Egyed, M
    Iványi, J
    Jáksó, P
    LEUKEMIA, 2000, 14 (06) : 1122 - 1126
  • [36] Development of BCR-ABL positive acute lymphoblastic leukemia in donor cells after allogeneic hematopoietic cell transplantation for Philadelphia-positive acute lymphoblastic leukemia
    Athanasiadou, A
    Stamatopoulos, K
    Sakellari, I
    Zorbas, I
    Gaitatzi, M
    Fassas, A
    Anagnostopoulos, A
    BONE MARROW TRANSPLANTATION, 2004, 34 (02) : 189 - 191
  • [37] Development of BCR-ABL positive acute lymphoblastic leukemia in donor cells after allogeneic hematopoietic cell transplantation for Philadelphia-positive acute lymphoblastic leukemia
    A Athanasiadou
    K Stamatopoulos
    I Sakellari
    I Zorbas
    M Gaitatzi
    A Fassas
    A Anagnostopoulos
    Bone Marrow Transplantation, 2004, 34 : 189 - 191
  • [38] Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl-expressing human leukemia cells
    Fiskus, Warren
    Pranpat, Michael
    Bali, Purva
    Balasis, Maria
    Kumaraswamy, Sandhya
    Boyapalle, Sandhya
    Rocha, Kathy
    Wu, Jie
    Giles, Francis
    Manley, Paul W.
    Atadja, Peter
    Bhalla, Kapil
    BLOOD, 2006, 108 (02) : 645 - 652
  • [39] ANALYSIS OF BCR-ABL KINASE DOMAIN MUTATIONS IN HUNGARIAN PATIENTS WITH IMATINIB RESISTANT CHRONIC MYELOID LEUKEMIA AND PHILADELPHIA POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA
    Meggyesi, N.
    Bors, A.
    Halm, G.
    Nahajevszky, S.
    Barta, A.
    Lueff, S.
    Batai, A.
    Remenyi, P.
    Masszi, T.
    Fekete, S.
    Ujj, G.
    Tordai, A.
    Andrikovics, H.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 : 538 - 538
  • [40] Drug Resistance and BCR-ABL Kinase Domain Mutations in Philadelphia Chromosome- Positive Acute Lymphoblastic Leukemia From the Imatinib to the Second- Generation Tyrosine Kinase Inhibitor Era
    Soverini, Simona
    De Benedittis, Caterina
    Papayannidis, Cristina
    Paolini, Stefania
    Venturi, Claudia
    Iacobucci, Ilaria
    Luppi, Mario
    Bresciani, Paola
    Salvucci, Marzia
    Russo, Domenico
    Sica, Simona
    Orlandi, Ester
    Intermesoli, Tamara
    Gozzini, Antonella
    Bonifacio, Massimiliano
    Rigolin, Gian Matteo
    Pane, Fabrizio
    Baccarani, Michele
    Cavo, Michele
    Martinelli, Giovanni
    CANCER, 2014, 120 (07) : 1002 - 1009
12345