Pyridone-based peptidomimetic inhibitors of interleukin-1 beta-converting enzyme (ICE)

被引：33
|
作者：
Semple, G
Ashworth, DM
Baker, GR
Batt, AR
Baxter, AJ
Benzies, DWM
Elliot, LH
Evans, DM
Franklin, RJ
Hudson, P
Jenkins, PD
Pitt, GR
Rooker, DP
Sheppard, A
Szelke, M
Yamamoto, S
Isomura, Y
机构：
[1] CHILWORTH RES CTR,FERRING RES INST,DEPT BIOL,SOUTHAMPTON SO16 7NP,HANTS,ENGLAND
[2] YAMANOUCHI INST DRUG DISCOVERY RES,INFECT DIS & IMMUNOL RES LABS,TSUKUBA,IBARAKI 305,JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(97)00220-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New potent, reversible inhibitors of recombinant human Interleukin-1 beta-converting enzyme (ICE, caspase-1) with significantly reduced peptide character are described. The compounds were designed by incorporation of pyridone and pyrimidone heterocyclic replacements for the P-2-P-3 amino acids of the native substrate and were optimised by manipulation of peripheral alkyl and aryl substituents. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：1337 / 1342
页数：6
相关论文
共 50 条
  • [41] SYNTHESIS AND EVALUATION OF DIACYLHYDRAZINES AS INHIBITORS OF THE INTERLEUKIN-1-BETA CONVERTING-ENZYME (ICE)
    GRAYBILL, TL
    DOLLE, RE
    HELASZEK, CT
    ATOR, MA
    STRASTERS, J
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (11) : 1197 - 1202
  • [42] Interleukin-1β, interleukin-18, and the interleukin-1β converting enzyme
    Dinarello, CA
    MOLECULAR MECHANISMS OF FEVER, 1998, 856 : 1 - 11
  • [43] Interleukin-1 beta converting enzyme (ICE): A novel therapeutic target in inflammatory bowel disease (IBD).
    McAlindon, ME
    Mahida, YR
    GASTROENTEROLOGY, 1996, 110 (04) : A961 - A961
  • [44] alpha-((tetronoyl)oxy)- and alpha-((tetramoyl)oxy)methyl ketone inhibitors of the interleukin-1 beta converting enzyme (ICE)
    Graybill, TL
    Prouty, CP
    Speier, GJ
    Hoyer, D
    Dolle, RE
    Helaszek, CT
    Ator, MA
    Uhl, J
    Strasters, J
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (01) : 41 - 46
  • [45] Cloning and expression of a rat brain interleukin-1 beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons
    Ni, BH
    Wu, X
    Du, YS
    Su, Y
    HamiltonByrd, E
    Rockey, PK
    Rosteck, P
    Poirier, GG
    Paul, SM
    JOURNAL OF NEUROSCIENCE, 1997, 17 (05): : 1561 - 1569
  • [46] Characterization of a myxoma virus-encoded serpin-like protein with activity against interleukin-1 beta-converting enzyme
    Petit, F
    Bertagnoli, S
    Gelfi, J
    Fassy, F
    BoucrautBaralon, C
    Milon, A
    JOURNAL OF VIROLOGY, 1996, 70 (09) : 5860 - 5866
  • [47] Peptide based interleukin-1β converting enzyme (ICE) inhibitors:: Synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex
    Okamoto, Y
    Anan, H
    Nakai, E
    Morihira, K
    Yonetoku, Y
    Kurihara, H
    Sakashita, H
    Terai, Y
    Takeuchi, M
    Shibanuma, T
    Isomura, Y
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1999, 47 (01) : 11 - 21
  • [48] INTERLEUKIN-1 (IL-1)-BETA AND IL-1-BETA CONVERTING-ENZYME (ICE) EXPRESSION IN CORNEAL CELLS
    LI, Q
    WENG, J
    VITAL, M
    HE, YG
    WILSON, SE
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1995, 36 (04) : S178 - S178
  • [49] Suppression of apoptosis by nitric oxide via inhibition of interleukin-1 beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases
    Dimmeler, S
    Haendeler, J
    Nehls, M
    Zeiher, AM
    JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (04): : 601 - 607
  • [50] Dysregulation of cytokine-mediated expression of interleukin-1 beta-converting enzyme in B-cell chronic lymphocytic leukemia.
    Hoffmann, R
    Duensing, S
    Sorgatz, M
    Grosse, J
    Wittke, F
    Ganser, A
    Atzpodien, J
    BLOOD, 1997, 90 (10) : 1580 - 1580
12345