Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475

被引：19

作者：

Niu, Siwen ^{[1
]}

Wang, Ning ^{[2
]}

Xie, Chun-Lan ^{[3
]}

Fan, Zuowang ^{[1
]}

Luo, Zhuhua ^{[1
]}

Chen, Hai-Feng ^{[3
]}

Yang, Xian-Wen ^{[1
]}

机构：

[1] State Ocean Adm, Inst Oceanog 3, Fujian Key Lab Marine Genet Resources, Key Lab Marine Genet Resources,State Key Lab Bree, 184 Daxue Rd, Xiamen 361005, Peoples R China

[2] Luxembourg Inst Hlth, Dept Oncol, 84 Val Fleuri, L-1526 Luxembourg, Luxembourg

[3] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target, Xiamen 361005, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2018年 / 71卷 / 07期

基金：

中国国家自然科学基金;

关键词：

DITERPENES; PRODUCTS; GROWTH;

D O I：

10.1038/s41429-018-0046-y

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chemical investigation on the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475 led to the isolation of a previously undescribed (roquefortine J, 1) and four known (2-5) roquefortine alkaloids, along with six ergosterol analogues (6-11). The planar structure of 1 was established mainly on the basis of extensive analysis of its 1D, 2D NMR, and HRESIMS spectra. The absolute configuration of 1 was determined by comparison of the calculated and experimental electronic circular dichroism spectra. Compounds 5, 6, and 7 exhibited potent anti-proliferative effects against HepG2 tumor cells with IC50 values of 7.0, 8.6, and 8.2 mu M, respectively.

引用

页码：658 / 661

页数：4

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