Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475

被引：19
|
作者：
Niu, Siwen [1 ]
Wang, Ning [2 ]
Xie, Chun-Lan [3 ]
Fan, Zuowang [1 ]
Luo, Zhuhua [1 ]
Chen, Hai-Feng [3 ]
Yang, Xian-Wen [1 ]
机构：
[1] State Ocean Adm, Inst Oceanog 3, Fujian Key Lab Marine Genet Resources, Key Lab Marine Genet Resources,State Key Lab Bree, 184 Daxue Rd, Xiamen 361005, Peoples R China
[2] Luxembourg Inst Hlth, Dept Oncol, 84 Val Fleuri, L-1526 Luxembourg, Luxembourg
[3] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target, Xiamen 361005, Peoples R China
来源：
JOURNAL OF ANTIBIOTICS | 2018年 / 71卷 / 07期
基金：
中国国家自然科学基金;
关键词：
DITERPENES; PRODUCTS; GROWTH;
D O I：
10.1038/s41429-018-0046-y
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Chemical investigation on the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475 led to the isolation of a previously undescribed (roquefortine J, 1) and four known (2-5) roquefortine alkaloids, along with six ergosterol analogues (6-11). The planar structure of 1 was established mainly on the basis of extensive analysis of its 1D, 2D NMR, and HRESIMS spectra. The absolute configuration of 1 was determined by comparison of the calculated and experimental electronic circular dichroism spectra. Compounds 5, 6, and 7 exhibited potent anti-proliferative effects against HepG2 tumor cells with IC50 values of 7.0, 8.6, and 8.2 mu M, respectively.
引用
收藏
页码：658 / 661
页数：4
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