Cytoprotective and anti-inflammatory effects of kernel extract from Adenanthera pavonina on lipopolysaccharide-stimulated rat peritoneal macrophages

被引：4
|
作者：
Koodalingam, Arunagirinathan [1 ]
Manikandan, Ramar [2 ]
Indhumathi, Munisamy [1 ]
Kaviya, Ethala Subramani [1 ]
机构：
[1] Sri Sankara Arts & Sci Coll, Dept Biotechnol, Kanchipuram 631561, Tamil Nadu, India
[2] Alagappa Univ, Dept Anim Hlth & Management, Karaikkudi 630003, Tamil Nadu, India
来源：
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2015年 / 8卷 / 02期
关键词：
Cytoprotective effect; Cytotoxicity; Macrophage; Inflammation; Nitric oxide; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; OXIDATIVE STRESS; NEURODEGENERATIVE DISORDERS; INFLAMMATORY MEDIATORS; DOWN-REGULATION; MAP KINASE; SUPEROXIDE; INHIBITION; ALZHEIMERS;
D O I：
10.1016/S1995-7645(14)60300-X
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objective: To investigate mechanism of anti-inflanunatory activity of Adenanthera pavonina A. pavonina) extracts. Methods: Rat peritoneal macrophages were treated with different concentrations of lipopolysaccharide and HA, in the presence and absence of kernel extract from A. pavonina. Nitric oxide, superoxide.anion generation, cell viability and nuclear fragmentation were investigated. Results: The pre treatment of kernel extract from A. pavonina suppressed nitric oxide, superoxide anion, cell death, nuclear fragmentation in lipopolysaccharide and H2O2, stimulated or induced macrophages, respectively. Conclusions: These results suggest that A. pavonina extract suppresses the intracellular peroxide production.
引用
收藏
页码：112 / 119
页数：8
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