Functional knockout of Kv1.3 channels suppresses effector memory phenotype acquisition in dominant negative Kv1.3-expressing human CD4+T cells

被引：0
|
作者：
Hu, Lina
Whartenby, Katharine
Allie, Rameeza
Calabresi, Peter
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ, Sch Med, Sidney Kimmel Canc Ctr, Baltimore, MD 21218 USA
来源：
CLINICAL IMMUNOLOGY | 2007年 / 123卷
关键词：
D O I：
10.1016/j.clim.2007.03.532
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页码：S124 / S124
页数：1
相关论文
共 50 条
  • [31] Kv1.3 blockade by ShK186 modulates CD4+ effector memory T-cell activity of patients with granulomatosis with polyangiitis
    Lintermans, Lucas L.
    Stegeman, Coen A.
    Munoz-Elias, Ernesto J.
    Tarcha, Eric J.
    Iadonato, Shawn P.
    Rutgers, Abraham
    Heeringa, Peter
    Abdulahad, Wayel H.
    RHEUMATOLOGY, 2024, 63 (01) : 198 - 208
  • [32] 18β-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells
    Fu, Xiao-Xing
    Du, Li-Li
    Zhao, Ning
    Dong, Qian
    Liao, Yu-Hua
    Du, Yi-Mei
    JOURNAL OF ETHNOPHARMACOLOGY, 2013, 148 (02) : 647 - 654
  • [33] Topical application of KPI-150, a potent inhibitor of Kv1.3 channels on effector memory T cells, demonstrates preclinical efficacy in atopic dermatitis model
    Olsen, C.
    Lustig, K.
    Iadonato, S.
    Tarcha, E.
    Guttman-Yassky, E.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2017, 137 (05) : S119 - S119
  • [34] Blockade of Kv1.3 potassium channels inhibits granzyme B production in human CD8+T lymphocytes.
    Hu, Lina
    Mullen, Katherine
    Allie, Rameeza
    Calabresi, Peter
    CLINICAL IMMUNOLOGY, 2006, 119 : S45 - S45
  • [35] Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes
    Panyi, G
    Bagdány, M
    Bodnár, A
    Vámosi, G
    Szentesi, G
    Jenei, A
    Mátyus, L
    Varga, S
    Waldmann, TA
    Gáspár, R
    Damjanovich, S
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) : 2592 - 2597
  • [36] Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases
    Schmitz, A
    Sankaranarayanan, A
    Azam, P
    Schmidt-Lassen, K
    Homerick, D
    Hänsel, W
    Wulff, H
    MOLECULAR PHARMACOLOGY, 2005, 68 (05) : 1254 - 1270
  • [37] Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation
    Ignacio Veytia-Bucheli, Jose
    Maria Jimenez-Vargas, Juana
    Isabel Melchy-Perez, Erika
    Alba Sandoval-Hernandez, Monserrat
    Domingos Possani, Lourival
    Rosenstein, Yvonne
    CELL COMMUNICATION AND SIGNALING, 2018, 16
  • [38] Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation
    José Ignacio Veytia-Bucheli
    Juana María Jiménez-Vargas
    Erika Isabel Melchy-Pérez
    Monserrat Alba Sandoval-Hernández
    Lourival Domingos Possani
    Yvonne Rosenstein
    Cell Communication and Signaling, 16
  • [39] The influence of 8-prenylnaringenin on the activity of voltage-gated kv1.3 potassium channels in human jurkat t cells
    Justyna Gąsiorowska
    Andrzej Teisseyre
    Anna Uryga
    Krystyna Michalak
    Cellular & Molecular Biology Letters, 2012, 17 : 559 - 570
  • [40] Vm24, a Natural Immunosuppressive Peptide, Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells
    Varga, Zoltan
    Gurrola-Briones, Georgina
    Papp, Ferenc
    de la Vega, Ricardo C. Rodriguez
    Pedraza-Alva, Gustavo
    Tajhya, Rajeev B.
    Gaspar, Rezso
    Cardenas, Luis
    Rosenstein, Yvonne
    Beeton, Christine
    Possani, Lourival D.
    Panyi, Gyorgy
    MOLECULAR PHARMACOLOGY, 2012, 82 (03) : 372 - 382
12345