Synthesis and in vitro antimicrobial evaluation of 5-(1-methyl-5-nitro-2-imidazolyl)-4H-1,2,4-triazoles

被引：36
|
作者：
Shafiee, A [1 ]
Sayadi, A [1 ]
Roozbahani, MH [1 ]
Foroumadi, A [1 ]
Kamal, F [1 ]
机构：
[1] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran 6451, Iran
来源：
ARCHIV DER PHARMAZIE | 2002年 / 335卷 / 10期
关键词：
1,2,4-triazoles; 5-nitroimidazoles; antimicrobial activity;
D O I：
10.1002/ardp.200290004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The increasing clinical importance of drug-resistant pathogens has lent additional urgency to antimicrobial research. Various 5-(l-methyl-5-nitro-2-imidazolyl)-4H-1,2,4-triazoles (4a-6f) were synthesized and tested in vitro for their antibacterial and antifungal activities. Compounds 4a and 4b exhibited significant effects against Bacillus subtilis at MIC ranges of 0.5-1 mug/mL and moderate effects against Staphylococcus aureus.
引用
收藏
页码：495 / 499
页数：5
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