Synthesis and in vitro antimicrobial evaluation of 5-(1-methyl-5-nitro-2-imidazolyl)-4H-1,2,4-triazoles

被引：36

作者：

Shafiee, A ^{[1
]}

Sayadi, A ^{[1
]}

Roozbahani, MH ^{[1
]}

Foroumadi, A ^{[1
]}

Kamal, F ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran 6451, Iran

来源：

ARCHIV DER PHARMAZIE | 2002年 / 335卷 / 10期

关键词：

1,2,4-triazoles; 5-nitroimidazoles; antimicrobial activity;

D O I：

10.1002/ardp.200290004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The increasing clinical importance of drug-resistant pathogens has lent additional urgency to antimicrobial research. Various 5-(l-methyl-5-nitro-2-imidazolyl)-4H-1,2,4-triazoles (4a-6f) were synthesized and tested in vitro for their antibacterial and antifungal activities. Compounds 4a and 4b exhibited significant effects against Bacillus subtilis at MIC ranges of 0.5-1 mug/mL and moderate effects against Staphylococcus aureus.

引用

页码：495 / 499

页数：5

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