Microemulsions as drug delivery systems to improve the solubility and the bioavailability of poorly water-soluble drugs

被引：138
|
作者：
He, Cai-Xia [1 ]
He, Zhong-Gui [2 ]
Gao, Jian-Qing [1 ]
机构：
[1] Zhejiang Univ, Inst Pharmaceut, Hangzhou 310058, Zhejiang, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China
来源：
EXPERT OPINION ON DRUG DELIVERY | 2010年 / 7卷 / 04期
关键词：
INTESTINAL LYMPHATIC TRANSPORT; IN-VITRO LIPOLYSIS; CHOLESTEROL-RICH MICROEMULSION; ORAL BIOAVAILABILITY; FORMULATION DEVELOPMENT; P-GLYCOPROTEIN; NANO-EMULSION; MEDIUM-CHAIN; GASTROINTESTINAL-TRACT; TRANSDERMAL DELIVERY;
D O I：
10.1517/17425241003596337
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Areas covered in this review: In this paper, the use and the characteristics of microemulsions as drug delivery vehicles are reviewed. As the formulations of the microemulsion always include a great amount of surfactant and co-surfactant, which may cause hemolysis or histopathological alterations of the tissue, the potential toxicity or the irritancy of microemulsions is also discussed in this paper. What the reader will gain: Developments of microemulsions for poorly water-soluble drugs in recent years are included in this review. Several factors limiting the commercial or clinical use of microemulsions are also discussed. Take home message: Considering the potential in enhanced drug uptake/permeation and facing the limitations, their unique properties make microemulsions a promising vehicle for poorly water-soluble drugs.
引用
收藏
页码：445 / 460
页数：16
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