Venovenous extracorporeal membrane oxygenation for acute respiratory failure

被引：126

作者：

Fan, Eddy ^{[1
,2
]}

Gattinoni, Luciano ^{[3
]}

Combes, Alain ^{[4
]}

Schmidt, Matthieu ^{[4
]}

Peek, Giles ^{[5
,6
]}

Brodie, Dan ^{[7
]}

Muller, Thomas ^{[8
]}

Morelli, Andrea ^{[9
]}

Ranieri, V. Marco ^{[9
]}

Pesenti, Antonio ^{[3
]}

Brochard, Laurent ^{[10
]}

Hodgson, Carol ^{[11
,12
]}

Van Kiersbilck, Cecile ^{[13
]}

Roch, Antoine ^{[14
]}

Quintel, Michael ^{[15
]}

Papazian, Laurent ^{[14
]}

机构：

[1] Univ Toronto, Interdept Div Crit Care Med, Toronto, ON, Canada

[2] Toronto Gen Hosp, Extracorporeal Life Support Program, 585 Univ Ave,PMB 11-123, Toronto, ON M5G 2N2, Canada

[3] Univ Milan, Dip Anestesia Rianimaz & Emergenza Urgenza, Fdn IRCCS Ca Granda, Ospendale Maggiore Policlin,Dip Fisiopatol Med Ch, Milan, Italy

[4] Univ Paris 06, Grp Hosp Pitie Salpetriere, Med Intens Care Unit, Inst Cardiometab & Nutr, Paris, France

[5] Albert Einstein Univ, Div Pediat Cardiothorac Surg, Montefiore Hlth Syst, New York, NY USA

[6] Albert Einstein Univ, Pediat Heart Ctr, Montefiore Hlth Syst, New York, NY USA

[7] Columbia Univ, Med Ctr, Div Pulm Allergy & Crit Care Med, New York Presbyterian Hosp, New York, NY USA

[8] Univ Regensburg, Dept Internal Med 2, Univ Med Ctr Regensburg, D-93053 Regensburg, Germany

[9] Univ Roma La Sapienza, Dept Anesthesiol & Intens Care, Policlin Umberto I, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[10] St Michaels Hosp, Keenan Res Ctr, Li Ka Shing Knowledge Inst, 30 Bond St, Toronto, ON M5B 1W8, Canada

[11] Monash Univ, Dept Epidemiol & Prevent Med, ANZIC RC, Melbourne, Vic 3004, Australia

[12] The Alfred, Physiotherapy Dept, Melbourne, Vic, Australia

[13] Aix Marseille Univ, Reanimat Detresses Resp & Infect Severes, CHU Nord, Marseille, France

[14] Aix Marseille Univ, Reanimat Detresses Resp & Infect Severes, CHU Nord, UMR CNRS 7278, Marseille, France

[15] Univ Klinikum Gottingen, Anaesthesiol Operat Intens Med 2, Gottingen, Germany

来源：

INTENSIVE CARE MEDICINE | 2016年 / 42卷 / 05期

关键词：

Critical care; Extracorporeal membrane oxygenation; Intensive care units; Respiratory distress syndrome; adult; Respiratory failure; Review; Ventilation; artificial; POSITIVE-PRESSURE VENTILATION; LONG-TERM OUTCOMES; LIFE-SUPPORT; MECHANICAL VENTILATION; DISTRESS-SYNDROME; MORTALITY RISK; ANTICOAGULATION; REMOVAL; ADULT; ECMO;

D O I：

10.1007/s00134-016-4314-7

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Despite expensive life-sustaining interventions delivered in the ICU, mortality and morbidity in patients with acute respiratory failure (ARF) remain unacceptably high. Extracorporeal membrane oxygenation (ECMO) has emerged as a promising intervention that may provide more efficacious supportive care to these patients. Improvements in technology have made ECMO safer and easier to use, allowing for the potential of more widespread application in patients with ARF. A greater appreciation of the complications associated with the placement of an artificial airway and mechanical ventilation has led clinicians and researchers to seek viable alternatives to providing supportive care in these patients. Thus, this review will summarize the current knowledge regarding the use of venovenous (VV)-ECMO for ARF and describe some of the recent controversies in the field, such as mechanical ventilation, anticoagulation and transfusion therapy, and ethical concerns in patients supported with VV-ECMO.

引用

页码：712 / 724

页数：13

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