Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics

被引：12

作者：

Park, Je Won ^{[2
]}

Nam, Sang-Jip ^{[1
]}

Yoon, Yeo Joon ^{[1
]}

机构：

[1] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea

[2] Korea Univ, Sch Biosyst & Biomed Sci, Seoul 02841, South Korea

来源：

BIOCHEMICAL PHARMACOLOGY | 2017年 / 134卷

基金：

新加坡国家研究基金会;

关键词：

Combinatorial biosynthesis; Sugar-containing antibiotics; Anti-infective and anti-proliferative; NATURAL-PRODUCT BIOSYNTHESIS; GLYCOSYLATED DERIVATIVES; STREPTOMYCES-VENEZUELAE; AMINOGLYCOSIDE ANTIBIOTICS; HETEROLOGOUS EXPRESSION; ENGINEERED BIOSYNTHESIS; ANTITUMOR-ACTIVITY; SYNTHETIC BIOLOGY; GENE-CLUSTER; POLYKETIDE SYNTHASES;

D O I：

10.1016/j.bcp.2016.10.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010-2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：56 / 73

页数：18

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