Development of a Continuous-Flow Microreactor for Asymmetric Sulfoxidation Using a Biomimetic Manganese Catalyst

被引：18
|
作者：
Dai, Wen [1 ,2 ]
Mi, Yuan [1 ,2 ]
Lv, Ying [1 ,2 ]
Chen, Bo [1 ,2 ]
Li, Guosong [1 ,2 ]
Chen, Guangwen [1 ,2 ]
Gao, Shuang [1 ,2 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
[2] Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 04期
关键词：
asymmetric sulfoxidation; biomimetic process; continuous flow conditions; microreactor; porphyrin-inspired catalyst; HYDROGEN-PEROXIDE; ENANTIOSELECTIVE SYNTHESIS; OXIDATION CATALYSIS; EPOXIDATION; SYSTEM; ORGANOCATALYSIS; SULFIDES; LIGANDS; COMPLEX; ALKENES;
D O I：
10.1002/adsc.201501023
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Asymmetric sulfoxidation catalyzed by a biomimetic manganese complex under continuous-flow microreactor is described. The reaction is conducted in microreactor, it can rapidly (<4min) oxidize a wide scope of sulfides with high yield (up to 91%) and excellent enantioselectivity (up to 99% ee), and allows shorter reaction times, easier scale-up and lower catalyst loadings than its batchwise counterpart. Additionally, a convenient numbering-up strategy for the scale-up of asymmetric sulfoxidation has been developed which enables a direct scaling of the reaction to 5g affording the corresponding sulfoxides within 20min.
引用
收藏
页码：667 / 671
页数：5
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