Synergism between CRISPR/Cas9 and LASER ART leads to elimination of HIV-1 with no rebound in Humanized Mice

被引：1
|
作者：
Gendelman, Howard [1 ,3 ]
Dash, Prasanta [1 ,3 ]
Edagwa, Benson [1 ,3 ]
Gorantla, Santhi [1 ,3 ]
Kaminski, Rafal [2 ]
Bella, Ramona [2 ]
Young, Won-Bin [2 ]
Khalili, Kamel [2 ]
机构：
[1] Univ Nebraska Med Ctr, Omaha, NE USA
[2] Temple Univ, Lewis Katz Sch Med, Dept Neurosci, Philadelphia, PA 19122 USA
[3] Univ Nebraska, Dept Pharmacol & Expt Neurosci, Omaha, NE 68182 USA
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2018年 / 77卷
关键词：
D O I：
10.1097/01.qai.0000532603.53717.02
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
D-110
引用
收藏
页码：42 / 42
页数：1
相关论文
共 50 条
  • [41] Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection
    Hou, Panpan
    Chen, Shuliang
    Wang, Shilei
    Yu, Xiao
    Chen, Yu
    Jiang, Meng
    Zhuang, Ke
    Ho, Wenzhe
    Hou, Wei
    Huang, Jian
    Guo, Deyin
    SCIENTIFIC REPORTS, 2015, 5
  • [42] Sequential admnistration of LASER ART and CR1SPR-Cas9 can facilitate H1V-1 elimination in humanized mice
    Gendelman, Howard E.
    Khalili, Kamel
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2019, 81 : 55 - 55
  • [43] Off-Target Analysis in Gene Editing and Applications for Clinical Translation of CRISPR/Cas9 in HIV-1 Therapy
    Atkins, Andrew
    Chung, Cheng-Han
    Allen, Alexander G. G.
    Dampier, Will
    Gurrola, Theodore E. E.
    Sariyer, Ilker K. K.
    Nonnemacher, Michael R. R.
    Wigdahl, Brian
    FRONTIERS IN GENOME EDITING, 2021, 3
  • [44] Targeting HIV-1 transcription factor binding sites using CRISPR/Cas9 to permanently deactivate latent provirus
    Chung, Cheng-Han
    Allen, Alexander G.
    Atkins, Andrew K.
    Costello, Robert
    Sullivan, Neil T.
    Nonnemacher, Michael R.
    Dampier, Will
    Wigdahl, Brian
    JOURNAL OF NEUROVIROLOGY, 2019, 25 (SUPPL 1) : S10 - S10
  • [45] CRISPR/Cas9 Ablation of Integrated HIV-1 Accumulates Proviral DNA Circles with Reformed Long Terminal Repeats
    Lai, Michele
    Maori, Eyal
    Quaranta, Paola
    Matteoli, Giulia
    Maggi, Fabrizio
    Sgarbanti, Marco
    Crucitta, Stefania
    Pacini, Simone
    Turriziani, Ombretta
    Antonelli, Guido
    Heeney, Jonathan L.
    Freer, Giulia
    Pistello, Mauro
    JOURNAL OF VIROLOGY, 2021, 95 (23)
  • [46] HIV-1 Proviral DNA Excision and Deactivation Using a CRISPR/Cas9 "Nickase" Targeted to the 5′ and 3′ LTR
    Scott, Tristan
    Saayman, Sheena
    Lazar, Daniel
    Arbuthnot, Patrick
    Rigoutsos, Isidor
    Morris, Kevin
    Kashanchi, Fatah
    Weinberg, Marco
    MOLECULAR THERAPY, 2015, 23 : S49 - S50
  • [47] A novel therapeutic vaccination delays cART-resistant HIV-1 reservoir rebound in HIV-1 infected humanized mice
    Cheng, Liang
    Li, Guangming
    Li, Dan
    Zhang, Zheng
    Li, Feng
    Zurawski, Sandra
    Zurawski, Gerard
    Levy, Yves
    Su, Lishan
    JOURNAL OF IMMUNOLOGY, 2016, 196
  • [48] SELECTION OF GRNAS TO TARGET THE HIV-1 QUASISPECIES WITH CRISPR/CAS9.
    Nonnemacher, M. R.
    Dampier, W.
    DeSimone, M.
    Pirrone, V
    Kercher, K.
    Passic, S.
    Williams, J.
    Wigdahl, B.
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2016, 11 : S32 - S33
  • [49] Crispr/Cas9 Engineered 61bp Deletion in the Calr Gene of Mice Leads to Development of Thrombocytosis
    Balligand, Thomas
    Achouri, Younes
    Chachoua, Ilyas
    Pecquet, Christian
    Defour, Jean-Philippe
    Constantinescu, Stefan N.
    BLOOD, 2016, 128 (22)
  • [50] Regulation of Cas9 by viral proteins Tat and Rev for HIV-1 inactivation
    Vergara-Mendoza, Moises
    Gomez-Quiroz, Luis E.
    Miranda-Labra, Roxana U.
    Fuentes-Romero, Luis L.
    Romero-Rodriguez, Damaris P.
    Gonzalez-Ruiz, Jonathan
    Hernandez-Rizo, Sharik
    Viveros-Rogel, Monica
    ANTIVIRAL RESEARCH, 2020, 180
12345