Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents

被引：21
|
作者：
He, Li Qin [1 ,2 ]
Liu, Jing [2 ]
Yin, Deng Ke [2 ]
Zhang, Yi Hua [1 ]
Wang, Xiao Shan [2 ]
机构：
[1] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China
[2] Anhui Univ Tradit Chinese Med, Anhui Key Lab Modernized Chinese Mat Med, Hefei 230031, Anhui, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 04期
关键词：
Matrine; Furoxan; Anti-tumor activity; HepG2; DONORS; APOPTOSIS;
D O I：
10.1016/j.cclet.2009.11.033
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of furoxan-based nitric oxide-releasing matrine derivatives (10a-f) were synthesized. The biological evaluation showed that compounds 10a, 10b, 10e and 10f had stronger cytotoxic activities than 5-fluorouracil against human hepatoma cells (HepG2) in vitro. (C) 2009 Yi Hua Zhang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：381 / 384
页数：4
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