Glycosylated hemoglobin and fetal growth in normal, gestational and insulin dependent diabetes mellitus pregnancies

Aims of the study were: evaluation of HbA(1)c levels ir;, the peripheral blood of pregnant women with insulin dependent diabetes, gestational diabetes, glucose intolerance, and healthy pregnant controls; implications of HbA(1)c concentration on detection and the control of women, with impaired carbohydrate metabolism in pregnancy; comparison of HbA(1)c levels with appearance of miscarriages, and premature deliveries; comparison of weight gain during pregnancy to HbA(1)c levels; comparison of difference from ideal body weight with HbA(1)c in diabetic pregnant women; comparison of neonatal birth weight and HbA(1)c levels. 290 pregnant women were enrolled to the study. The highest value of HbA(1)c teas in the group IDDM pregnant women (7.7% +/- 1.8%), and the lowest value of HbA(1)c was in the control group (4.1% +/- 0.5%). Statistically significant coefficients were found between HbA(1)c and weight gain during pregnancy, between weight deviation from ideal body weight and HbA(1)c (r = 0.54 and r = 0.48 respectively); and between, newborns weight and HbA(1)c (r = 0.52). Well regulated glycemia and intensive pregnancy follow-up of diabetic women reduces stillbirths, neonatal complications and neonatal mucrosomia incidence.