Nickel-Catalyzed Cross-Coupling of Ethyl Chlorofluoroacetate with Aryl Bromides

被引：7
|
作者：
Li, Han [1 ,2 ]
Sheng, Jie [1 ,2 ]
Wu, Bing-Bing [1 ,2 ]
Li, Yan [1 ,2 ]
Wang, Xi-Sheng [1 ,2 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2021年 / 16卷 / 13期
基金：
中国博士后科学基金; 美国国家科学基金会;
关键词：
monofluoroacetation; aryl halides; ethyl chlorofluoroacetate; nickel; cross-coupling; ALPHA-FLUORO; FLUORINATION; ACIDS; REAGENTS; POSITION; KETONES; ESTERS;
D O I：
10.1002/asia.202100348
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A combinatorial nickel-catalyzed monofluoroalkylation of aryl bromides with the industrial raw regent ethyl chlorofluoroacetate has been developed. The two key factors to successful conversion are the combination of nickel with readily available nitrogen and phosphine ligands and the using of a mixture of different solvents. Mechanistic investigations indicated a new zinc regent might generated in situ and be involved in the reaction process.
引用
收藏
页码：1741 / 1744
页数：4
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