Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage

被引：23
|
作者：
Nair, Sunitha [2 ]
Hande, M. Prakash
Lim, Lina H. K. [1 ,2 ,3 ]
机构：
[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Inflammat & Canc Lab, Dept Physiol, Singapore 117456, Singapore
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, NUS Immunol Program, Singapore 117456, Singapore
[3] Natl Univ Singapore, Yong Loo Lin Sch Med, NUS Grad Sch Integrat Sci & Engn, Singapore 117456, Singapore
来源：
CANCER LETTERS | 2010年 / 294卷 / 01期
关键词：
Tumor suppressor gene; Proliferation; DNA damage; STRESS-INDUCED APOPTOSIS; LIPOCORTIN; HYPERTHERMIA; EXPRESSION; ACTIVATION; HSP70;
D O I：
10.1016/j.canlet.2010.01.026
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Stress proteins protect cells against the effects of heat stress, such as cell death and DNA damage. We wished to determine if Annexin-1 (ANXA1) could mediate heat-induced growth arrest and DNA damage in MCF7 breast cancer cells. Heat induced a significant growth arrest at 4 h-24 h. Growth arrest and heat-induced DNA damage were significantly inhibited in MCF7 cells over-expressing ANXA1. These effects were associated with enhanced ERK activation and reduction in JNK phosphorylation. This study demonstrates that ANXA1, which we recently reported as a possible tumor suppressor gene, can protect cells from heat-induced growth arrest and DNA damage. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：111 / 117
页数：7
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