Histone deacetylase 6 plays an important role in TGF-β-induced murine Treg cell differentiation by regulating cell proliferation

被引：10

作者：

Lee, Ji Hyeon ^{[1
]}

Kim, Hyeong Su ^{[1
]}

Jang, Sung Woong ^{[1
]}

Lee, Gap Ryol ^{[1
]}

机构：

[1] Sogang Univ, Dept Life Sci, 35 Baekbeom Ro, Seoul 04107, South Korea

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

T-CELLS; HDAC6; INHIBITOR; SELF-TOLERANCE; ACETYLATION; MECHANISMS; PROTEIN; FOXP3; TRANSCRIPTION; LYMPHOCYTES; ENTEROPATHY;

D O I：

10.1038/s41598-022-27230-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Regulatory T (Treg) cells maintain immune homeostasis by preventing abnormal or excessive immune responses. Histone deacetylase 6 (HDAC6) regulates expression of Foxp3, and thus, Treg cell differentiation; however, its role in Treg cell differentiation is unclear and somewhat controversial. Here, we investigated the role of HDAC6 in TGF-beta-induced murine Treg cells. HDAC6 expression was higher in Treg cells than in other T helper cell subsets. Pharmacological inhibitors of HDAC6 selectively inhibited Treg cell differentiation and suppressive function. A specific HDAC6 inhibitor induced changes in global gene expression by Treg cells. Of these changes, genes related to cell division were prominently affected. In summary, HDAC6 plays an important role in TGF-beta-induced murine Treg cell differentiation by regulating cell proliferation.

引用

页数：12

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