Evaluation of anti-inflammatory activity of Vernonia cinerea Less. extract in rats

被引：42

作者：

Mazumder, UK ^{[1
]}

Gupta, M ^{[1
]}

Manikandan, L ^{[1
]}

Bhattacharya, S ^{[1
]}

Haldar, PK ^{[1
]}

Roy, S ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Pharmaceut Technol, Kolkata 700032, W Bengal, India

来源：

PHYTOMEDICINE | 2003年 / 10卷 / 2-3期

关键词：

Vernonia cinerea; paw edema; granuloma; anti-inflammatory;

D O I：

10.1078/094471103321659915

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The methanol extract of the whole plant of Vernonia cinerea Less. was evaluated for its anti-inflammatory activity in acute (carrageenin, histamine and serotonin induced rat paw edema) and a chronic model (cotton pouch induced granuloma). The methanol extract (250 and 500 mg/kg(-1) p.o.) exhibited significant activity (p < 0.001) against all phlogistic agents used in a dose dependant manner. In the chronic model (cotton pouch granuloma method) the methanol extract exhibited significant anti-inflammatory activity. All these effects were compared with standard drug phenylbutazone (100 mg/kg(-1) p.o.).

引用

页码：185 / 188

页数：4

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