Evaluation of anti-inflammatory activity of Vernonia cinerea Less. extract in rats

被引：42
|
作者：
Mazumder, UK [1 ]
Gupta, M [1 ]
Manikandan, L [1 ]
Bhattacharya, S [1 ]
Haldar, PK [1 ]
Roy, S [1 ]
机构：
[1] Jadavpur Univ, Dept Pharmaceut Technol, Kolkata 700032, W Bengal, India
来源：
PHYTOMEDICINE | 2003年 / 10卷 / 2-3期
关键词：
Vernonia cinerea; paw edema; granuloma; anti-inflammatory;
D O I：
10.1078/094471103321659915
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The methanol extract of the whole plant of Vernonia cinerea Less. was evaluated for its anti-inflammatory activity in acute (carrageenin, histamine and serotonin induced rat paw edema) and a chronic model (cotton pouch induced granuloma). The methanol extract (250 and 500 mg/kg(-1) p.o.) exhibited significant activity (p < 0.001) against all phlogistic agents used in a dose dependant manner. In the chronic model (cotton pouch granuloma method) the methanol extract exhibited significant anti-inflammatory activity. All these effects were compared with standard drug phenylbutazone (100 mg/kg(-1) p.o.).
引用
收藏
页码：185 / 188
页数：4
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