In vivo magnetic resonance spectroscopy in the evaluation of mitochondrial disorders

被引：5
|
作者：
Arias-Mendoza, F [1 ]
机构：
[1] Columbia Univ, Dept Radiol, Hatch Ctr MR Res, Neurol Inst Basement, New York, NY 10032 USA
来源：
MITOCHONDRION | 2004年 / 4卷 / 5-6期
关键词：
31P MR spectroscopy; chemical shift imaging; in vivo metabolism; neuromuscular disease; mitochondrial dysfunction; mitochondrial disorders;
D O I：
10.1016/j.mito.2004.07.034
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Magnetic resonance spectroscopy (MRS) has been utilized to study several metabolic pathways in vivo and in live tissues in vitro non-invasively. Despite its inherited lack of sensitivity, its application has extended all the way to in situ human tissues and organs since proper technical advancements were devised. Examples of its application described here demonstrate the value of in vivo MRS as a technique that determines parameters of mitochondrial dysfunction directly and indirectly which could be of value for the diagnosis, prognosis, and follow-up of mitochondrial disorders. (C) 2004 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
引用
下载
收藏
页码：491 / 501
页数：11
相关论文
共 50 条
  • [1] ASSESSMENT OF IN VIVO MITOCHONDRIAL METABOLISM BY MAGNETIC RESONANCE SPECTROSCOPY
    Befroy, Douglas E.
    Petersen, Kitt Falk
    Rothman, Douglas L.
    Shulman, Gerald I.
    METHODS IN ENZYMOLOGY, VOL 457: MITOCHONDRIAL FUNCTION, PARTB MITOCHONDRIAL PROTEIN KINASES, PROTEIN PHOSPHATASES AND MITOCHONDRIAL DISEASES, 2009, 457 : 373 - 393
  • [2] Magnetic resonance spectroscopy in vivo: applications in neurological disorders
    Arnold, DL
    De Stefano, N
    ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1997, 18 (06): : 321 - 329
  • [3] In vivo magnetic resonance spectroscopy and its application to neuropsychiatric disorders
    Stanley, JA
    CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2002, 47 (04): : 315 - 326
  • [4] In vivo proton magnetic resonance spectroscopy in the evaluation of the endometrium
    Sarac, K
    Celik, O
    Hascalik, S
    Alkan, A
    Mizrak, B
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2004, 83 (08) : 751 - 757
  • [5] Magnetic resonance in mitochondrial disorders
    van der Knaap, M
    Valk, J
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2004, 1657 : 7 - 8
  • [6] Proton magnetic resonance spectroscopy -: An in vivo window to study neurodegenerative disorders
    Linfante, I
    Ashizawa, T
    ARCHIVES OF NEUROLOGY, 1999, 56 (12) : 1446 - 1447
  • [7] Evaluation of neuron-glia integrity by in vivo proton magnetic resonance spectroscopy: Implications for psychiatric disorders
    Xu, Haiyun
    Zhang, Handi
    Zhang, Jie
    Huang, Qingjun
    Shen, Zhiwei
    Wu, Renhua
    NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2016, 71 : 563 - 577
  • [8] Magnetic resonance imaging and spectroscopy in the evaluation of neuromuscular disorders and fatigue
    Tonon, Caterina
    Gramegna, Laura Ludovica
    Lodi, Raffaele
    NEUROMUSCULAR DISORDERS, 2012, 22 : S187 - S191
  • [9] Magnetic resonance spectroscopy of premalignant and malignant endometrial disorders: a feasibility of in vivo study
    Celik, O
    Hascalik, S
    Sarac, K
    Meydanli, MM
    Alkan, A
    Mizrak, B
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2005, 118 (02) : 241 - 245
  • [10] In vivo proton magnetic resonance spectroscopy for the evaluation of hepatic encephalopathy in dogs
    Carrera, Ines
    Kircher, Patrick R.
    Meier, Dieter
    Richter, Henning
    Beckman, Katrin
    Dennler, Matthias
    AMERICAN JOURNAL OF VETERINARY RESEARCH, 2014, 75 (09) : 818 - 827
12345