Synthesis, Molecular Docking of New N-(2-(4-(1h-Pyrrol-1-yl)Phenoxy)-N′-2-(Substituted Phenoxy)Acetyl)Acetohydrazides Derivatives as Antibacterial and Antitubercular Analogs

Newer series of N-(2-(4-(1H-pyrrol-1-yl)phenoxy)-N'-(2-(substituted phenoxy) acetyl)acetohydrazides 6(a-k) was prepared by the reaction of 2-(4-(1H-pyrrol-1-yl)phenoxy) acetohydrazide (4) and substituted phenoxy acids 5(a-k) in distilled N',N'-dimethyl formamide using coupling agent 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate and N',N'-diisopropylethylamine as a catalytic agent. The newly described compounds showed same kind of binding interface at the active site of the enzyme as that of ligand moiety. All 11 stated molecules were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis H(37)Rv strain and antibacterial activity against Gram +ve Staphylococcus aureus and Gram-ve Escherichia coli strain, all the tested molecules have shown prominent inhibitory concentration values towards both tubercular and bacterial strains.