The use of marine-derived bioactive compounds as potential hepatoprotective agents

被引：34
|
作者：
Nair, Dileep G. [1 ]
Weiskirchen, Ralf [2 ]
Al-Musharafi, Salma K. [1 ]
机构：
[1] Sur Coll Appl Sci, Dept Appl Biotechnol, Minist Higher Educ, Sur, Oman
[2] RWTH Univ Hosp Aachen, Inst Clin Chem & Pathobiochem, Aachen, Germany
来源：
ACTA PHARMACOLOGICA SINICA | 2015年 / 36卷 / 02期
关键词：
liver fibrosis; hepatoprotective agent; marine compound; Scytonemin; Pacifenol; Epitaondiol; Stypotriol; Contignasterol; Xestobergsterol; Clathriol; Hymenialdisine; Hyrtiosal; HEPATIC STELLATE CELLS; SMOOTH-MUSCLE-CELLS; SULTANATE-OF-OMAN; FACTOR-KAPPA-B; SHO-SAIKO-TO; LIVER FIBROSIS; NATURAL-PRODUCTS; OXIDATIVE STRESS; FISH-OIL; INFLAMMATORY CYTOKINES;
D O I：
10.1038/aps.2014.114
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The marine environment may be explored as a rich source for novel drugs. A number of marine-derived compounds have been isolated and identified, and their therapeutic effects and pharmacological profiles are characterized. In the present review, we highlight the recent studies using marine compounds as potential hepatoprotective agents for the treatment of liver fibrotic diseases and discuss the proposed mechanisms of their activities. In addition, we discuss the significance of similar studies in Oman, where the rich marine life provides a potential for the isolation of novel natural, bioactive products that display therapeutic effects on liver diseases.
引用
收藏
页码：158 / 170
页数：13
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