The use of marine-derived bioactive compounds as potential hepatoprotective agents

被引：34
|
作者：
Nair, Dileep G. [1 ]
Weiskirchen, Ralf [2 ]
Al-Musharafi, Salma K. [1 ]
机构：
[1] Sur Coll Appl Sci, Dept Appl Biotechnol, Minist Higher Educ, Sur, Oman
[2] RWTH Univ Hosp Aachen, Inst Clin Chem & Pathobiochem, Aachen, Germany
来源：
ACTA PHARMACOLOGICA SINICA | 2015年 / 36卷 / 02期
关键词：
liver fibrosis; hepatoprotective agent; marine compound; Scytonemin; Pacifenol; Epitaondiol; Stypotriol; Contignasterol; Xestobergsterol; Clathriol; Hymenialdisine; Hyrtiosal; HEPATIC STELLATE CELLS; SMOOTH-MUSCLE-CELLS; SULTANATE-OF-OMAN; FACTOR-KAPPA-B; SHO-SAIKO-TO; LIVER FIBROSIS; NATURAL-PRODUCTS; OXIDATIVE STRESS; FISH-OIL; INFLAMMATORY CYTOKINES;
D O I：
10.1038/aps.2014.114
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The marine environment may be explored as a rich source for novel drugs. A number of marine-derived compounds have been isolated and identified, and their therapeutic effects and pharmacological profiles are characterized. In the present review, we highlight the recent studies using marine compounds as potential hepatoprotective agents for the treatment of liver fibrotic diseases and discuss the proposed mechanisms of their activities. In addition, we discuss the significance of similar studies in Oman, where the rich marine life provides a potential for the isolation of novel natural, bioactive products that display therapeutic effects on liver diseases.
引用
收藏
页码：158 / 170
页数：13
相关论文
共 50 条
  • [1] The use of marine-derived bioactive compounds as potential hepatoprotective agents
    Dileep G Nair
    Ralf Weiskirchen
    Salma K Al-Musharafi
    Acta Pharmacologica Sinica, 2015, 36 : 158 - 170
  • [2] Prospects of marine-derived compounds as potential therapeutic agents for glioma
    Liu, Ying
    Zhou, Zhiyang
    Sun, Shusen
    PHARMACEUTICAL BIOLOGY, 2024, 62 (01) : 513 - 526
  • [3] Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics
    Alves, Ana
    Sousa, Emilia
    Kijjoa, Anake
    Pinto, Madalena
    MOLECULES, 2020, 25 (11):
  • [4] Marine-derived bioactive compounds for neuropathic pain: pharmacology and therapeutic potential
    Mishra, Swapnil
    Mishra, Yogesh
    Kumar, Ashutosh
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2025,
  • [5] Marine-derived bioactive materials as antibiofilm and antivirulence agents
    Jeong, Geum-Jae
    Khan, Fazlurrahman
    Tabassum, Nazia
    Cho, Kyung-Jin
    Kim, Young-Mog
    TRENDS IN BIOTECHNOLOGY, 2024, 42 (10) : 1288 - 1304
  • [6] Potential Pharmacological Resources: Natural Bioactive Compounds from Marine-Derived Fungi
    Jin, Liming
    Quan, Chunshan
    Hou, Xiyan
    Fan, Shengdi
    MARINE DRUGS, 2016, 14 (04)
  • [7] BIOACTIVE COMPOUNDS FROM THAI MARINE-DERIVED FUNGI
    Kittakoop, Prasat
    PHARMACEUTICAL BIOLOGY, 2012, 50 (05) : 650 - 650
  • [8] Marine-derived Phoma—the gold mine of bioactive compounds
    Mahendra Rai
    Aniket Gade
    Beata Zimowska
    Avinash P. Ingle
    Pramod Ingle
    Applied Microbiology and Biotechnology, 2018, 102 : 9053 - 9066
  • [9] Exploring the therapeutic potential of marine-derived bioactive compounds against COVID-19
    Singh, Rachana
    Chauhan, Niketa
    Kuddus, Mohammed
    ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2021, 28 (38) : 52798 - 52809
  • [10] Exploring the therapeutic potential of marine-derived bioactive compounds against COVID-19
    Rachana Singh
    Niketa Chauhan
    Mohammed Kuddus
    Environmental Science and Pollution Research, 2021, 28 : 52798 - 52809
12345