A simple Lewis acid induced reaction of phenols with electrophiles: Synthesis of functionalized 4H-chromenes and ortho-benzylphenols

被引:15
|
作者
Sreenivasulu, Chinnabattigalla [1 ]
Thadathil, Ditto Abraham [1 ]
Pal, Sumit [1 ]
Gedu, Satyanarayana [1 ]
机构
[1] Indian Inst Technol Hyderabad, Dept Chem, Kandi 502285, Telangana, India
关键词
4H-chromenes; phenol; ketones; chalcones; Lewis acid; NUCLEOPHILIC-SUBSTITUTION-REACTIONS; PROTECTING GROUP-FREE; FACILE SYNTHESIS; EFFICIENT SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; METAL; ALCOHOLS; HYDROARYLATION; STYRENES; CHROMENES;
D O I
10.1080/00397911.2019.1689268
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Lewis acid ZnCl2 promoted cyclization protocol to 4H-chromenes is accomplished, using readily available phenols and acetophenones as starting materials. Interestingly, the process is feasible under the solvent free environment. Synthesis of a variety of 4H-chromenes have been accomplished using this strategy. In addition, this concept is extended to the synthesis of ortho-benzylphenols by treating phenols either with styrenes or secondary benzylic alcohols.
引用
收藏
页码:112 / 122
页数:11
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