A simple Lewis acid induced reaction of phenols with electrophiles: Synthesis of functionalized 4H-chromenes and ortho-benzylphenols

被引：15

作者：

Sreenivasulu, Chinnabattigalla ^{[1
]}

Thadathil, Ditto Abraham ^{[1
]}

Pal, Sumit ^{[1
]}

Gedu, Satyanarayana ^{[1
]}

机构：

[1] Indian Inst Technol Hyderabad, Dept Chem, Kandi 502285, Telangana, India

来源：

SYNTHETIC COMMUNICATIONS | 2020年 / 50卷 / 01期

关键词：

4H-chromenes; phenol; ketones; chalcones; Lewis acid; NUCLEOPHILIC-SUBSTITUTION-REACTIONS; PROTECTING GROUP-FREE; FACILE SYNTHESIS; EFFICIENT SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; METAL; ALCOHOLS; HYDROARYLATION; STYRENES; CHROMENES;

D O I：

10.1080/00397911.2019.1689268

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lewis acid ZnCl2 promoted cyclization protocol to 4H-chromenes is accomplished, using readily available phenols and acetophenones as starting materials. Interestingly, the process is feasible under the solvent free environment. Synthesis of a variety of 4H-chromenes have been accomplished using this strategy. In addition, this concept is extended to the synthesis of ortho-benzylphenols by treating phenols either with styrenes or secondary benzylic alcohols.

引用

页码：112 / 122

页数：11

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