Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones

被引：0
|
作者：
Cobeljic, Bozidar R. [1 ]
Zivkovic, Marijana B. [2 ]
Matic, Ivana Z. [3 ]
Novakovic, Irena T. [2 ]
Sladic, Dusan M. [1 ]
Andelkovic, Katarina K. [1 ]
Krstic, Natalija M. [2 ]
机构：
[1] Univ Belgrade, Fac Chem, Studentski Trg 12-16,POB 158, Belgrade, Serbia
[2] Univ Belgrade, Inst Chem Technol & Met, Dept Chem, Njegoseva 12, Belgrade 11000, Serbia
[3] Inst Oncol & Radiol Serbia, Pasterova 14, Belgrade, Serbia
来源：
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2021年 / 86卷 / 05期
关键词：
3-oxo-alpha; beta-unsaturated steroids; hydrazones; square-planar complexes; cytotoxicity; antimicrobial activity; RAPID COLORIMETRIC ASSAY; ANTIFUNGAL; COPPER(II);
D O I：
10.2298/JSC201211083C
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete H-1 and C-13 assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that the new steroidal thiosemicarbazone complexes were significantly less cytotoxic than the corresponding steroidal thiosemicarbazones. In addition, complexes showed lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones.
引用
收藏
页码：459 / 468
页数：10
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