Flavonoid rutinosides from Cinnamomum parthenoxylon leaves and their hepatoprotective and antioxidant activity

被引：21

作者：

Pardede, Antoni ^{[1
,2
]}

Adfa, Morina ^{[3
]}

Juliari Kusnanda, Arif ^{[3
]}

Ninomiya, Masayuki ^{[1
]}

Koketsu, Mamoru ^{[1
]}

机构：

[1] Gifu Univ, Dept Chem & Biomol Sci, Fac Engn, 1-1 Yanagido, Gifu 5011193, Japan

[2] Islamic Univ Kalimantan, Dept Chem Educ, Jl Adhyaksa 2 Kayu Tangi, Banjarmasin 70123, Indonesia

[3] Bengkulu Univ, Fac Math & Nat Sci, Dept Chem, Jalan Raya WR Supratman, Kandang Limun 38371, Bengkulu, Indonesia

来源：

MEDICINAL CHEMISTRY RESEARCH | 2017年 / 26卷 / 09期

关键词：

Cinnamomum parthenoxylon; Flavonoid rutinoside; Hepatoprotective activity; Antioxidant activity; ANTILEUKEMIC ACTIVITY; PHENOLIC-COMPOUNDS; CYTOTOXICITY; CONSTITUENTS;

D O I：

10.1007/s00044-017-1916-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cinnamomum parthenoxylon tree belongs to the Lauraceae family. In this study, flavonoid rutinosides were isolated from C. parthenoxylon leaves and their hepatoprotective and antioxidant activity were evaluated. The EtOAc fraction of C. parthenoxylon leaves showed potent hepatoprotective activity on tert-butyl hydroperoxideinduced cytotoxicity in HepG2 cells and also higher antioxidant activity. Ultra-performance liquid chromatography electrospray ionization mass spectrometry analysis revealed that flavonoid rutinosides; rutin, nicotiflorin, and isorhoifolin are major constituents in the EtOAc fraction. The catechol group on B ring in the structure of rutin holds potential for hepatoprotective and antioxidant activity.

引用

页码：2074 / 2079

页数：6

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