Is the Brain Undernourished in Alzheimer's Disease?

被引:10
|
作者
Aquilani, Roberto [1 ]
Costa, Alfredo [2 ,3 ,4 ]
Maestri, Roberto [5 ]
Cotta Ramusino, Matteo [2 ,3 ,4 ]
Perini, Giulia [2 ,3 ,4 ]
Boselli, Mirella [6 ]
Iadarola, Paolo [1 ]
Buonocore, Daniela [1 ]
Verri, Manuela [1 ]
Dossena, Maurizia [1 ]
Boschi, Federica [7 ]
机构
[1] Univ Pavia, Dept Biol & Biotechnol Lazzaro Spallanzani, I-27100 Pavia, Italy
[2] IRCCS C Mondino Fdn, Unit Behav Neurol, I-27100 Pavia, Italy
[3] IRCCS C Mondino Fdn, Ctr Cognit Disorders & Dement, I-27100 Pavia, Italy
[4] Univ Pavia, Dept Brain & Behav Sci, I-27100 Pavia, Italy
[5] Istituti Clin Sci Maugeri IRCCS, Montescano Inst, Dept Biomed Engn, I-27040 Montescano, Italy
[6] IRCCS, Istituti Clin Scientifici Maugeri Spa Societa, Unita Riabilitazione Neuromotoria Gravi Cerebrole, I-27040 Montescano, Italy
[7] Univ Pavia, Dept Drug Sci, I-27100 Pavia, Italy
关键词
Alzheimer; CSF amino acid levels; amino acid CSF; plasma ratio; nutritional state; CHAIN AMINO-ACIDS; MILD COGNITIVE IMPAIRMENT; GROWTH-FACTOR EXPRESSION; CEREBRAL GLUCOSE-METABOLISM; C-13; MAGNETIC-RESONANCE; CEREBROSPINAL-FLUID; AMYLOID-BETA; OXIDATIVE STRESS; IN-VIVO; GLUTAMINE-SYNTHETASE;
D O I
10.3390/nu14091872
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Cerebrospinal fluid (CSF) amino acid (AA) levels and CSF/plasma AA ratios in Alzheimer Disease (AD) in relation to nutritional state are not known. Methods: In 30 fasting patients with AD (46% males, 74.4 +/- 8.2 years; 3.4 +/- 3.2 years from diagnosis) and nine control (CTRL) matched subjects, CSF and venous blood samples were drawn for AA measurements. Patients were stratified according to nutritional state (Mini Nutritional Assessment, MNA, scores). Results: Total CSF/plasma AA ratios were lower in the AD subpopulations than in NON-AD (p < 0.003 to 0.017. In combined malnourished (16.7%; MNA < 17) and at risk for malnutrition (36.6%, MNA 17-24) groups (CG), compared to CTRL, all essential amino acids (EAAs) and 30% of non-EAAs were lower (p < 0.018 to 0.0001), whereas in normo-nourished ADs (46.7%, MNA > 24) the CSF levels of 10% of EAAs and 25% of NON-EAAs were decreased (p < 0.05 to 0.00021). CG compared to normo-nourished ADs, had lower CSF aspartic acid, glutamic acid and Branched-Chain AA levels (all, p < 0.05 to 0.003). CSF/plasma AA ratios were <1 in NON-AD but even lower in the AD population. Conclusions: Compared to CTRL, ADs had decreased CSF AA Levels and CSF/plasma AA ratios, the degree of which depended on nutritional state.
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页数:27
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