Effect of experimental hypercholesterolaemia on K+ channel α-subunit mRNA levels in rabbit hearts

被引：5

作者：

Varga, Angelika

Bagossi, Peter

Tozser, Jozsef

Peitl, Barna

Szilvassy, Zoltan

机构：

[1] Univ Debrecen, Dept Pharmacol & Pharmacotherapy, Med & Hlth Sci Ctr, H-4032 Debrecen, Hungary

[2] Univ Debrecen, Dept Biochem & Mol Biol, Med & Hlth Sci Ctr, H-4032 Debrecen, Hungary

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2007年 / 562卷 / 1-2期

关键词：

K+ channel; mRNA expression; hypercholesterolaemia;

D O I：

10.1016/j.ejphar.2007.02.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the effect of dietary cholesterol on gene transcription of delayed rectifier (I-Kr - ERG1 and IKs - KvLQT1) and transient outward (I-to,I-fast - Kv4.2 and Kv4.3) potassium channel subunits in rabbit hearts using real-time quantitative reverse transcription-polymerase chain reaction (RTPCR). While the level of Kv4.3 mRNA did not change, both Kv4.2 and ERG1 mRNAs were downregulated, whereas the level of KvLQT1 was increased in hypercholesterolaemic rabbits, indicating that hypercholesterolaernia altered ventricular K+ channel alpha-subunit gene transcription. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：130 / 131

页数：2

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