Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar:: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population

被引：55
|
作者：
Matsuoka, H
Wang, JC
Hirai, M
Arai, M
Yoshida, S
Kobayashi, T
Jalloh, A
Lin, K
Kawamoto, F
机构：
[1] Jichi Med Sch, Dept Med Zool, Minami Kawachi, Tochigi 3290498, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Biomed Chem, Tokyo, Japan
[3] Nagoya Univ, Grad Sch Med, Dept Adv Med Sci, Showa Ku, Nagoya, Aichi, Japan
[4] Dept Med Res, Div Parasitol, Upper Myanmar, Myanmar
[5] Oita Univ, Fac Med, Inst Sci Res, Oita 87011, Japan
来源：
JOURNAL OF HUMAN GENETICS | 2004年 / 49卷 / 10期
关键词：
glucose-6-phosphate dehydrogenase deficiency; Mahidol; malaria; Myanmar; primaquine;
D O I：
10.1007/s10038-004-0187-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We conducted a survey of malaria diagnoses and treatments in remote areas of Myanmar. Blood specimens from more than 1,000 people were collected by the finger-prick method, and 121 (11%) of these people were found to be glucose-6-phosphate dehydrogenase (G6PD) deficient. Of these 121, 50 consented to analysis of the G6PD genome. We read the G6PD sequences of these subjects and found 45 cases of G6PD Mahidol (487G>A), two of G6PD Coimbra (592C>T), two of G6PD Union (1360C>T), and one of G6PD Canton (1376G>T). Taken together with data from our previous report, 91.3% (73/80) of G6PD variants were G6PD Mahidol. This finding suggests that the Myanmar population is derived from homogeneous ancestries and are different from Thai, Malaysian, and Indonesian populations.
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页码：544 / 547
页数：4
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