Immunobiology of Long Noncoding RNAs

被引:361
|
作者
Atianand, Maninjay K. [1 ]
Caffrey, Daniel R. [1 ]
Fitzgerald, Katherine A. [1 ]
机构
[1] Univ Massachusetts, Sch Med, Program Innate Immun, Div Infect Dis & Immunol,Dept Med, Worcester, MA 01605 USA
来源
关键词
noncoding RNA; lincRNA; lncRNA; immunity; gene regulation; TRANSCRIPTIONAL CONTROL; CELL-DIFFERENTIATION; DENDRITIC CELLS; CUTTING EDGE; XIST RNA; CHROMATIN; EXPRESSION; PROTEIN; GENE; ELEMENTS;
D O I
10.1146/annurev-immunol-041015-055459
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene regulation in diverse biological contexts. lncRNAs are remarkably versatile molecules that interact with RNA, DNA, or proteins to promote or restrain the expression of protein-coding genes. Activation of immune cells is associated with dynamic changes in expression of genes, the products of which combat infectious microorganisms, initiate repair, and resolve inflammatory responses in cells and tissues. Recent evidence indicates that lncRNAs play important roles in directing the development of diverse immune cells and controlling the dynamic transcriptional programs that are a hallmark of immune cell activation. The importance of these molecules is underscored by their newly recognized roles in inflammatory diseases. In this review, we discuss the contribution of lncRNAs in the development and activation of immune cells and their roles in immune-related diseases. We also discuss challenges faced in identifying biological functions for this large and complex class of genes.
引用
收藏
页码:177 / 198
页数:22
相关论文
共 50 条
  • [21] Cytotopic localization by long noncoding RNAs
    Batista, Pedro J.
    Chang, Howard Y.
    CURRENT OPINION IN CELL BIOLOGY, 2013, 25 (02) : 195 - 199
  • [22] Long Noncoding RNAs and Their Role in Oncogenesis
    Bure, I. V.
    Kuznetsova, E. B.
    Zaletaev, D. V.
    MOLECULAR BIOLOGY, 2018, 52 (06) : 787 - 798
  • [23] The Diversity of Long Noncoding RNAs and Their Generation
    Wu, Huang
    Yang, Li
    Chen, Ling-Ling
    TRENDS IN GENETICS, 2017, 33 (08) : 540 - 552
  • [24] Genome Regulation by Long Noncoding RNAs
    Chang, Howard Y.
    FASEB JOURNAL, 2016, 30
  • [25] Long noncoding RNAs and the genetics of cancer
    S W Cheetham
    F Gruhl
    J S Mattick
    M E Dinger
    British Journal of Cancer, 2013, 108 : 2419 - 2425
  • [26] Long Noncoding RNAs and Their Role in Oncogenesis
    I. V. Bure
    E. B. Kuznetsova
    D. V. Zaletaev
    Molecular Biology, 2018, 52 : 787 - 798
  • [27] Long Noncoding RNAs in Radiation Response
    L. V. Shulenina
    V. F. Mikhailov
    G. D. Zasukhina
    Biology Bulletin, 2020, 47 : 1627 - 1636
  • [28] Long Noncoding RNAs and Cardiac Disease
    Greco, Simona
    Somoza, Antonio Salgado
    Devaux, Yvan
    Martelli, Fabio
    ANTIOXIDANTS & REDOX SIGNALING, 2018, 29 (09) : 880 - 901
  • [29] Long noncoding RNAs in cancer metastasis
    Liu, S. John
    Dang, Ha X.
    Lim, Daniel A.
    Feng, Felix Y.
    Maher, Christopher A.
    NATURE REVIEWS CANCER, 2021, 21 (07) : 446 - 460
  • [30] Long Noncoding RNAs, Chromatin, and Development
    Caley, Daniel P.
    Pink, Ryan C.
    Trujillano, Daniel
    Carter, David R. F.
    THESCIENTIFICWORLDJOURNAL, 2010, 10 : 90 - 102