Is tissue plasminogen activator a threat to neurons?

被引：26

作者：

Traynelis, SF ^{[1
]}

Lipton, SA

机构：

[1] Emory Univ, Dept Pharmacol, Atlanta, GA 30322 USA

[2] Burnham Inst, Ctr Neurosci & Aging, La Jolla, CA USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 01期

关键词：

D O I：

10.1038/83289

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The clot-busting drug tissue plasminogen activator (tPA) is currently the only FDA-approved therapy for acute stroke. However, increasing evidence suggests that tPA can also contribute to excitotoxic neuronal damage in animal models of stroke.

引用

页码：17 / 18

页数：2

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