Motor impairment induced by oral exposure to methylmercury in adult mice

The effects of oral exposure to methylmercury chloride (MeHg) on locomotor control and activity in adult mice were investigated in the present study. MeHg was diluted in drinking water (0.20 and 40 mg/L - as methylmercury chloride) and locomotion (spontaneous locomotor activity) and motor impairment tests (beam walking. footprint and clasping) were performed at 7.14 and 21 days after the beginning, of the treatment. MeHg exposure caused a significant decrease in spontaneous locomotor activity and this effect was dose- and time-dependent. Significant dose- and duration-dependent increases in beam walking latency were observed following chronic MeHg exposure. Furthermore. dose- and duration-dependent locomotor deficits on footprint coordination were also observed. Taken together. these results show, that MeHg-induced impairment on locomotor activity is not limited to exposures that take place during neural development. We discuss the possible relationship between our findings and the similar clinical signs observed in adult humans exposed to MeHg. (C) 2004 Elsevier B.V. All rights reserved.