A general strategy for the synthesis of amino-substituted 2-pyridones using a palladium-catalyzed amination reaction

被引：0
|
作者：
Kim, Young Ha
Kim, Yeong-Joon
Chang, Sung-Youn
Kim, Bum Tae
Heo, Jung-Nyoung [1 ]
机构：
[1] Chungnam Natl Univ, Dept Chem, Taejon 305764, South Korea
[2] Korea Res Inst Chem Technol, Ctr Med Chem, Taejon 305600, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2007年 / 28卷 / 05期
关键词：
2-pyridone; aminopyridine; palladium-catalyzed amination; microwave; Buchwald-Hartwig amination;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel library of amino-substituted 2-pyridones has been constructed through a two-step sequence of microwave-promoted Buchwald-Hartwig amination of 2-benzyloxy halopyridines followed by debenzylation. Microwave-promoted arriination of 3- or 4-halopyridine in the presence of a suitable palladium catalyst and ligand system provided amino-substituted 2-benzyloxypyridines in excellent yields. Then, debenzylation of 2benzyloxypyridines afforded the corresponding 2-pyridones with high efficiency.
引用
收藏
页码：777 / 782
页数：6
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