Relationship between N,N-dialkyl chitosan monolayer and corresponding vesicle

被引：12

作者：

Li, Mingchun ^{[1
]}

Su, Sheng ^{[1
]}

Xin, Meihua ^{[1
]}

Liao, Yaozu ^{[1
]}

机构：

[1] Huaqiao Univ, Coll Mat Sci & Engn, Fujian 362021, Peoples R China

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2007年 / 311卷 / 01期

基金：

中国国家自然科学基金;

关键词：

N; N-dialkyl chitosan; monolayer; compressibility; vesicle; drug-release;

D O I：

10.1016/j.jcis.2006.12.082

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The properties of N, N-dialkyl chitosan monolayers and corresponding vesicles have been studied by LB technique and drug-release experiment. With increasing molecular weight of chitosan backbone and/or length of alkyl chain, both the compressibility and collapse pressure of N, N-dialkyl chitosan monolayer are enhanced. The experiments on drug-release behavior of N, N-dialkyl chitosan vesicles show that the drug-release rate and the equilibrium drug-release ratio are decreased with increasing the compressibility of corresponding monolayer. It is worth noticing that there is a linear relationship between the compressibility of N, N-dialkyl chitosan monolayers and the equilibrium drug-release ratio of the vesicles. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：285 / 288

页数：4

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